Results 11 to 20 of about 4,572 (262)

Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. [PDF]

PLoS ONE, 2014
Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic ...
Marco Fazzari, Andrés Trostchansky, Francisco J Schopfer, Sonia R Salvatore, Beatriz Sánchez-Calvo, Dario Vitturi, Raquel Valderrama, Juan B Barroso, Rafael Radi, Bruce A Freeman, Homero Rubbo   +10 more
doaj   +6 more sources

Enantio- and Periselective Nitroalkene Diels-Alder Reactions Catalyzed by Helical-Chiral Hydrogen Bond Donor Catalysts

Molecules, 2013
Helical-chiral double hydrogen bond donor catalysts promote the nitroalkene Diels-Alder reaction in an enantio- and periselective manner. This represents the first asymmetric catalytic nitroalkene Diels-Alder reaction via LUMO-lowering catalysis. To gain
Zhili Peng, Norito Takenaka
exaly   +3 more sources

Fatty acid nitroalkene reversal of established lung fibrosis

Redox Biology, 2022
Tissue fibrosis occurs in response to dysregulated metabolism, pro-inflammatory signaling and tissue repair reactions. For example, lungs exposed to environmental toxins, cancer therapies, chronic inflammation and other stimuli manifest a phenotypic ...
Adolf Koudelka, Mauricio Rojas, Nilay Mitash   +2 more
exaly   +3 more sources

Imidazoline‐Proline and Imidazoline‐Prolinate Ligands for Copper‐Catalyzed Asymmetric Exo‐Selective [3 + 2] Cycloaddition of Iminoesters with Nitroalkenes

ChemistryEurope
Diphenylethylenediamine‐derived imidazoline‐amino acid derivatives are designed as nonphosphine chiral nitrogen ligands for metal‐catalyzed exo‐selective [3 + 2] cycloaddition reaction of iminoesters with nitroalkenes.
Yan Yu, Takuya Shimada, Chihiro Tokumitsu, Ayaka Fujiwara, Takayoshi Arai   +4 more
doaj   +2 more sources

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies [PDF]

Redox Biology, 2023
Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species.
Lisa Hong, Dennis C. Braden, Yaoning Zhao, John J. Skoko, Fei Chang, Steven R. Woodcock, Crystall Uvalle, Allison Casey, Katherine Wood, Sonia R. Salvatore, Alparslan Asan, Trey Harkness, Adeola Fagunloye, Mortezaali Razzaghi, Adam Straub, Maria Spies, Daniel D. Brown, Adrian V. Lee, Francisco Schopfer, Bruce A. Freeman, Carola A. Neumann   +20 more
doaj   +2 more sources

Deep eutectic solvent for the synthesis of (E)- Nitroalkene via microwave assisted Henry reaction

Current Research in Green and Sustainable Chemistry, 2021
Deep eutectic solvents (DESs) are modified versions of ionic liquids and are formed by the fusion of polar components (liquids or solids) via hydrogen bonding interactions.
M. Shaibuna, K. Hiba, K. Sreekumar
doaj   +2 more sources

Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents

Redox Biology, 2021
Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (NO2 ...
Marco Fazzari, Steven R Woodcock, Pascal Rowart   +2 more
exaly   +3 more sources

Modeling of the General Trends of Reactivity and Regioselectivity in Cyclopentadiene–Nitroalkene Diels–Alder Reactions [PDF]

Molecules
This study presents a theoretical investigation of the electronic properties of mono- and pentasubstituted cyclopentadiene analogs and variously substituted conjugated nitroalkenes bearing electron-donating and electron-withdrawing groups.
Adrianna Fałowska, Stanisław Grzybowski, Daniel Kapuściński, Karol Sambora, Agnieszka Łapczuk   +4 more
doaj   +2 more sources

Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2 [PDF]

Communications Chemistry
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs.
Francisco J. Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J. Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V. González   +17 more
doaj   +2 more sources

The Cyclic Nitronate Route to Pharmaceutical Molecules: Synthesis of GSK’s Potent PDE4 Inhibitor as a Case Study

Molecules, 2020
An efficient asymmetric synthesis of GlaxoSmithKline’s potent PDE4 inhibitor was accomplished in eight steps from a catechol-derived nitroalkene. The key intermediate (3-acyloxymethyl-substituted 1,2-oxazine) was prepared in a straightforward manner by ...
Evgeny V. Pospelov, Ivan S. Golovanov, Sema L. Ioffe, Alexey Yu. Sukhorukov   +3 more
doaj   +1 more source