Results 31 to 40 of about 1,025,504 (341)

Performance evaluation of pipelines for mapping, variant calling and interval padding, for the analysis of NGS germline panels

open access: yesBMC Bioinformatics, 2021
Background Next-generation sequencing (NGS) represents a significant advancement in clinical genetics. However, its use creates several technical, data interpretation and management challenges.
Maria Zanti   +8 more
doaj   +1 more source

Scanning electron microscopy of Rydberg-excited Bose-Einstein condensates [PDF]

open access: yesNew J. Phys. 16 083034 (2014), 2014
We report on the realization of high resolution electron microscopy of Rydberg-excited ultracold atomic samples. The implementation of an ultraviolet laser system allows us to excite the atom, with a single-photon transition, to Rydberg states. By using the electron microscopy technique during the Rydberg excitation of the atoms, we observe a giant ...
arxiv   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Morphological, biological, and genomic characterization of a newly isolated lytic phage Sfk20 infecting Shigella flexneri, Shigella sonnei, and Shigella dysenteriae1

open access: yesScientific Reports, 2021
Shigellosis, caused by Shigella bacterial spp., is one of the leading causes of diarrheal morbidity and mortality. An increasing prevalence of multidrug-resistant Shigella species has revived the importance of bacteriophages as an alternative therapy to ...
Bani Mallick   +2 more
doaj   +1 more source

Thermokinetic Study of Aluminum-Induced Crystallization of a-Si: The Effect of Al Layer Thickness

open access: yesNanomaterials, 2023
The effect of the aluminum layer on the kinetics and mechanism of aluminum-induced crystallization (AIC) of amorphous silicon (a-Si) in (Al/a-Si)n multilayered films was studied using a complex of in situ methods (simultaneous thermal analysis ...
Sergey M. Zharkov   +8 more
doaj   +1 more source

Electron transparent graphene windows for environmental scanning electron microscopy in liquids and dense gases [PDF]

open access: yes, 2012
Due to its ultrahigh electron transmissivity in a wide electron energy range, molecular impermeability, high electrical conductivity and excellent mechanical stiffness the suspended graphene membranes appear to be a nearly ideal window material for in situ (in vivo) environmental electron microscopy of nano- and mesoscopic objects (including bio ...
arxiv   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

open access: yesMolecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina   +17 more
wiley   +1 more source

Probing electronic structure in berkelium and californium via an electron microscopy nanosampling approach

open access: yesNature Communications, 2021
The obtention and study of actinide elements is challenging due to various factors including their radioactivity and scarcity. Herein, the authors characterize the atomic and electronic structure of Am, Cm, Bk, and Cf compounds using a transmission ...
Alexander Müller   +5 more
doaj   +1 more source

Efficient first principles simulation of electron scattering factors for transmission electron microscopy [PDF]

open access: yes, 2018
Electron microscopy is a powerful tool for studying the properties of materials down to their atomic structure. In many cases, the quantitative interpretation of images requires simulations based on atomistic structure models. These typically use the independent atom approximation that neglects bonding effects, which may, however, be measurable and of ...
arxiv   +1 more source

Development of an Ontology for an Integrated Image Analysis Platform to enable Global Sharing of Microscopy Imaging Data [PDF]

open access: yesProceedings of the 15th International Semantic Web Conference (Kobe, Japan), 2016, 2021
Imaging data is one of the most important fundamentals in the current life sciences. We aimed to construct an ontology to describe imaging metadata as a data schema of the integrated database for optical and electron microscopy images combined with various bio-entities.
arxiv  

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