Results 41 to 50 of about 229,241 (159)

A method for benchmarking genetic screens reveals a predominant mitochondrial bias

Molecular Systems Biology, 2021
We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome‐wide CRISPR screen data and methods for analyzing them.
Mahfuzur Rahman, Maximilian Billmann, Michael Costanzo, Michael Aregger, Amy H Y Tong, Katherine Chan, Henry N Ward, Kevin R Brown, Brenda J Andrews, Charles Boone, Jason Moffat, Chad L Myers   +11 more
doaj   +1 more source

Structural determinants of mitochondrial STAT3 targeting and function

Mitochondrial Communications
Signal transducer and activator of transcription (STAT) 3 has been found within mitochondria in addition to its canonical role of shuttling between cytoplasm and nucleus during cytokine signaling.
Isabelle J. Marié, Tanaya Lahiri, Özlem Önder, Kojo S.J. Elenitoba-Johnson, David E. Levy   +4 more
doaj   +1 more source

Respiratory processes in non-photosynthetic plastids

Frontiers in Plant Science, 2015
Chlororespiration is a respiratory process located in chloroplast thylakoids which consists in an electron transport chain from NAD(P)H to oxygen. This respiratory chain involves the NAD(P)H dehydrogenase complex, the plastoquinone pool and the plastid ...
Marta eRenato, Marta eRenato, Albert eBoronat, Albert eBoronat, Joaquín eAzcón-Bieto   +4 more
doaj   +1 more source

Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis.

PLoS Computational Biology, 2012
The mitochondrial electron transport chain transforms energy satisfying cellular demand and generates reactive oxygen species (ROS) that act as metabolic signals or destructive factors.
Vitaly A Selivanov, Marta Cascante, Mark Friedman, Mark F Schumaker, Massimo Trucco, Tatyana V Votyakova   +5 more
doaj   +1 more source

Fluoride affects distribution of absorbed excitation energy more in favour of photosystem 1

Biologia Plantarum, 2010
The effects of fluoride on the photosynthetic electron transport chain have been studied in spinach thylakoid membranes. Inhibition in photosystem (PS) 2 electron transport rates and a subsequent increase in PS 1 electron transport rate indicated a ...
P. Singh-Rawal, A. Jajoo, S. Bharti
doaj   +1 more source

Improved efficiency of NiOx-based p-i-n perovskite solar cells by using PTEG-1 as electron transport layer

APL Materials, 2017
We present efficient p-i-n type perovskite solar cells using NiOx as the hole transport layer and a fulleropyrrolidine with a triethylene glycol monoethyl ether side chain (PTEG-1) as electron transport layer.
Bart G. H. M. Groeneveld, Mehrdad Najafi, Bauke Steensma, Sampson Adjokatse, Hong-Hua Fang, Fatemeh Jahani, Li Qiu, Gert H. ten Brink, Jan C. Hummelen, Maria Antonietta Loi   +9 more
doaj   +1 more source

Melatonin and the electron transport chain

Cellular and Molecular Life Sciences, 2017
Melatonin protects the electron transport chain (ETC) in multiple ways. It reduces levels of ·NO by downregulating inducible and inhibiting neuronal nitric oxide synthases (iNOS, nNOS), thereby preventing excessive levels of peroxynitrite. Both ·NO and peroxynitrite-derived free radicals, such as ·NO2, hydroxyl (·OH) and carbonate radicals (CO3 ...
openaire   +3 more sources

Investigating the Effect of Incorporating Dimethylaminopropyl Side Chains into a Naphthalenediimide‐Based Conjugated Polymer

Advanced Electronic Materials
Two approaches—fractional side‐chain truncation and complementary interactions—are employed in this study. In fractional side‐chain truncation, NDIDmap with the naphthalene diimide (NDI) group and the 3‐(dimethylamino)propyl (Dmap) chain is incorporated ...
Tzu‐Lun Liu, Yu‐Ying Lai
doaj   +1 more source

Evidence for a hydrogenosomal-type anaerobic ATP generation pathway in Acanthamoeba castellanii.

PLoS ONE, 2013
Diverse, distantly-related eukaryotic lineages have adapted to low-oxygen environments, and possess mitochondrion-related organelles that have lost the capacity to generate adenosine triphosphate (ATP) through oxidative phosphorylation. A subset of these
Michelle M Leger, Ryan M R Gawryluk, Michael W Gray, Andrew J Roger   +3 more
doaj   +1 more source

Mitochondrial Dysfunction in the Inflammatory Process of Neurodegenerative Diseases

Biomedicines
Neurodegenerative diseases share a mitochondrial–immune axis in which impaired oxidative phosphorylation reshapes neuronal metabolism and drives chronic inflammation.
Salvatore Nesci
doaj   +1 more source