Results 61 to 70 of about 531,300 (297)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Effect of exogenously applied 20-hydroxyecdysone on the efficiency of primary photosynthetic processes substantially differs across plant species

Photosynthetica, 2020
The effects of 20-hydroxyecdysone on the primary photosynthetic processes (PPP) were examined across twelve plant species using the OJIP chlorophyll fluorescence analysis.
D. HOLÁ, K. FRIMLOVÁ, M. KOČOVÁ, H. MARKOVÁ, O. ROTHOVÁ, L. TŮMOVÁ   +5 more
doaj   +1 more source

Dissection of photosynthetic electron transport process in sweet sorghum under heat stress. [PDF]

PLoS ONE, 2013
Plant photosynthesis and photosystem II (PSII) are susceptible to high temperature. However, photosynthetic electron transport process under heat stress remains unclear.
Kun Yan, Peng Chen, Hongbo Shao, Chuyang Shao, Shijie Zhao, Marian Brestic   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Current rectification in molecular junctions produced by local potential fields [PDF]

, 2010
The transport properties of a octane-dithiol (ODT) molecule coupled to Au(001) leads are analyzed using density functional theory and non-equilibrium Green functions.
Bułka, Bogdan R., García-Suárez, Víctor M., Kostyrko, Tomasz, Lambert, Colin J.   +3 more
core   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Chlorophyll fluorescence in the evaluation of photosynthetic electron transport chain inhibitors in the pea

Revista Ciência Agronômica
The study aimed to evaluate the behavior of the chair of photosynthetic electron transport in the presence of DCMU and atrazine in detached leaves of pea through simultaneous measurements of the kinetics of fluorescence transient, fluorescence delayed ...
Marcio Espinosa Farias, Emanuela Garbin Martinazzo, Marcos Antonio Bacarin   +2 more
doaj   +1 more source

A method for benchmarking genetic screens reveals a predominant mitochondrial bias

Molecular Systems Biology, 2021
We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome‐wide CRISPR screen data and methods for analyzing them.
Mahfuzur Rahman, Maximilian Billmann, Michael Costanzo, Michael Aregger, Amy H Y Tong, Katherine Chan, Henry N Ward, Kevin R Brown, Brenda J Andrews, Charles Boone, Jason Moffat, Chad L Myers   +11 more
doaj   +1 more source

Physiological Evidence for Isopotential Tunneling in the Electron Transport Chain of Methane-Producing Archaea [PDF]

, 2017
Many, but not all, organisms use quinones to conserve energy in their electron transport chains. Fermentative bacteria and methane-producing archaea (methanogens) do not produce quinones but have devised other ways to generate ATP. Methanophenazine (MPh)
Buan, Nicole R., Duszenko, Nikolas
core   +1 more source

Charge transport across metal/molecular (alkyl) monolayer-Si junctions is dominated by the LUMO level

, 2011
We compare the charge transport characteristics of heavy doped p- and n-Si-alkyl chain/Hg junctions. Photoelectron spectroscopy (UPS, IPES and XPS) results for the molecule-Si band alignment at equilibrium show the Fermi level to LUMO energy difference ...
Antoine Kahn, Ayelet Vilan, David Cahen, E. Rhoderick, Han Zuilhof, Hossam Haick, L. Esaki, Leeor Kronik, Lior Segev, Luc Scheres, Omer Yaffe, S. M. Sze, Sreenivasa Reddy Puniredd, Tal Ely, Yabing Qi   +14 more
core   +3 more sources