Results 91 to 100 of about 605,158 (291)

Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]

, 2013
The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin, Danyal, Karamatullah, Dean, Dennis R., Duval, Simon, Hoffman, Brian M., Lytle, Anna K., Seefeldt, Lance C., Shaw, Sudipta   +7 more
core   +2 more sources

STUDIES ON PHOTOACTIVATED ELECTRON-TRANSPORT SYSTEMS. I. REDUCTION OF HEMIN AND ANTHRAQUINONESULFONATE AS MEDIATED BY PYRIDINIUM IONS AND PHOTOEXCITED RUTHENIUM(II) COMPLEXES [PDF]

Chemistry Letters, 1977
Abstract Photoexcited state of tris(2,2′-bipyridine)ruthenium(II) ion serves as a good reducing agent, if EDTA is present in the solution. Pyridyl radical and 4,4′-bipyridinium cation radical were obtained by this means of photoirradiation, and proved to be useful as mediators for catalytic reduction of Hemin and 9,10-anthraquinone-l ...
Keisuke Takuma, Makoto Kajiwara, Taku Matsuo   +2 more
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Redox Biology, 2014
Efavirenz (EFV) is an anti-retroviral drug frequently combined with isoniazid (INH) to treat HIV-1/tuberculosis co-infected patients. Both drugs have been associated with idiosyncratic liver injury (DILI), but combined anti-retroviral and anti-tubercular
Kang Kwang Lee, Urs A. Boelsterli
doaj   +1 more source

Improved Efficiency Roll-Off and Operational Lifetime of Organic Light-Emitting Diodes with a Tetradentate Platinum(II) Complex by Using an n-Doped Electron-Transporting Layer [PDF]

, 2021
Weiqiang Liu, Liang Zhou, Long Yi Jin, Gang Cheng   +3 more
openalex   +1 more source

Aharonov-Bohm Interferometry with Interacting Quantum Dots: Spin Configurations, Asymmetric Interference Patterns, Bias-Voltage-Induced Aharonov-Bohm Oscillations, and Symmetries of Transport Coefficients

, 2002
We study electron transport through multiply-connected mesoscopic geometries containing interacting quantum dots. Our formulation covers both equilibrium and non-equilibrium physics.
A. Stern, A. Yacoby, A.L. Yeyati, A.W. Holleitner, B.L. Altshuler, B.L. Altshuler, C. Bruder, D. Boese, D. Goldhaber-Gordon, D. Loss, D.V. Averin, D.V. Averin, F. Simmel, G. Hackenbroich, H. Akera, J. König, J. König, J. König, J. König, J. König, J. König, J. Schmid, Jürgen König, K. Kang, L.I. Glazman, L.J. van der Pauw, M. Büttiker, M. Büttiker, P.A. Mello, P.G. Silvestrov, R. Baltin, R. Baltin, R. Landauer, R. Schuster, S.M. Cronenwett, T.K. Ng, T.V. Shahbazyan, U. Gerland, W. Hofstetter, W. Izumida, W.G. van der Wiel, Y. Gefen, Y. Ji, Y. Meir, Y. Meir, Y. Oreg, Yuval Gefen   +46 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Fano Resonances in Electronic Transport through a Single Electron Transistor

, 1999
We have observed asymmetric Fano resonances in the conductance of a single electron transistor resulting from interference between a resonant and a nonresonant path through the system. The resonant component shows all the features typical of quantum dots,
A. Shibatani, D. Goldhaber-Gordon, D. Goldhaber-Gordon, D. Goldhaber-Gordon, D. Mahalu, D.G. Baksheyev, E. Tekman, E.B. Foxman, F. Cerdeira, F. Simmel, G. Breit, H. Feshbach, H. Schmidt, Hadas Shtrikman, I.L. Aleiner, J. Feist, J. Göres, J. Schmid, J. Weis, J.A. Simpson, J.U. Nöckel, L.I. Glazman, L.P. Kouwenhoven, M. A. Kastner, M. Büttiker, M.A. Kastner, P.J. Price, R. Landauer, R.A. Serota, R.C. Ashoori, R.K. Adair, S. Heemeyer, S.M. Cronenwett, S.M. Cronenwett, T.A. Fulton, T.K. Ng, U. Fano, U. Fano, U. Meirav, V. Madhavan, W. Porod, Y. Meir   +41 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source