Results 111 to 120 of about 657,635 (323)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle

Experimental Physiology
The effect of biological sex on rates of skeletal muscle mitochondrial respiration supported by creatine‐dependent phosphate shuttling was previously unknown.
Emily J. Ferguson, Lauren J. Pacitti, Justin Bureau, Callum J. Pufahl, Eveline Menezes, Tanner Stokes, Shivam Gandhi, Luca J. Delfinis, Craig A. Simpson, Christopher G. R. Perry, Brendon J. Gurd, Chris McGlory   +11 more
doaj   +1 more source

Electro-enzymatic processes in mitochondria [PDF]

BIO Web of Conferences
Four enzymatic complexes form the electron transport chain of the mitochondrion. Complexes I and II are current generator half-elements, that create electron flows with the participation of the enzymes NADH dehydrogenase and Succinate dehydrogenase ...
Shapovalov Yuriy, Gumarova Lyazzat, Massuadin Arailym   +2 more
doaj   +1 more source

Modeling techniques for quantum cascade lasers

, 2014
Quantum cascade lasers are unipolar semiconductor lasers covering a wide range of the infrared and terahertz spectrum. Lasing action is achieved by using optical intersubband transitions between quantized states in specifically designed multiple-quantum ...
Jirauschek, Christian, Kubis, Tillmann
core   +1 more source

Transport of spin-anisotropy without spin currents [PDF]

, 2013
We revisit the transport of spin-degrees of freedom across an electrically and thermally biased tunnel junction between two ferromagnets with non-collinear magnetizations.
Das, Sourin, Hell, Michael, Wegewijs, Maarten Rolf   +2 more
core   +2 more sources

Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II

Journal of Biological Chemistry, 2017
Succinate-driven reverse electron transport (RET) through complex I is hypothesized to be a major source of reactive oxygen species (ROS) that induces permeability transition pore (PTP) opening and damages the heart during ischemia/reperfusion.
P. Korge, S. John, G. Calmettes, J. Weiss   +3 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

From Coulomb blockade to the Kondo regime in a Rashba dot [PDF]

, 2007
We investigate the electronic transport in a quantum wire with localized Rashba interaction. The Rashba field forms quasi-bound states which couple to the continuum states with an opposite spin direction.
A. C. Hewson, David Sánchez, E. I. Rashba, E. I. Rashba, J. C. Egues, J. Schmid, LI. Glazman, LI. Glazman, Llorenç Serra, Rosa López   +9 more
core   +3 more sources

Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson’s disease

Scientific Reports, 2019
Multiple system atrophy (MSA) is a neurodegenerative disease characterised by glial cytoplasmic inclusions (GCIs), containing α-synuclein. Mutated COQ2, encoding an enzyme essential for co-enzyme Q10 (CoQ10) biosynthesis, has been associated with MSA ...
S. Foti, I. Hargreaves, Stephanie Carrington, A. Kiely, H. Houlden, J. Holton   +5 more
semanticscholar   +1 more source