Results 71 to 80 of about 657,635 (323)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Tumour immunogenicity goes with the (mitochondrial electron) flow

Molecular Oncology
Mitochondrial metabolism and electron transport chain (ETC) function are essential for tumour proliferation and metastasis. However, the impact of ETC function on cancer immunogenicity is not well understood. In a recent study, Mangalhara et al.
Asma Ahmed, Stephen W. G. Tait
doaj   +1 more source

Responses of Linear and Cyclic Electron Flow to Nitrogen Stress in an N-Sensitive Species Panax notoginseng

Frontiers in Plant Science, 2022
Nitrogen (N) is a primary factor limiting leaf photosynthesis. However, the mechanism of N-stress-driven photoinhibition of the photosystem I (PSI) and photosystem II (PSII) is still unclear in the N-sensitive species such as Panax notoginseng, and thus ...
Zhu Cun, Zhu Cun, Zhu Cun, Hong-Min Wu, Hong-Min Wu, Hong-Min Wu, Jin-Yan Zhang, Jin-Yan Zhang, Jin-Yan Zhang, Sheng-Pu Shuang, Sheng-Pu Shuang, Sheng-Pu Shuang, Jie Hong, Jie Hong, Jie Hong, Jun-Wen Chen, Jun-Wen Chen, Jun-Wen Chen   +17 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Natural product as a lead for impairing mitochondrial respiration in cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry
The impact of the isoxazole derivative of usnic acid, ISOXUS (formerly known as 2b) on cancer and non-cancerous cell metabolism was investigated. ISOXUS significantly reduced the utilisation of most metabolic substrates that produce NADH or FADH2 ...
Agnieszka Pyrczak-Felczykowska, Anna-Karina Kaczorowska, Artur Giełdoń, Alicja Braczko, Ryszard T. Smoleński, Jędrzej Antosiewicz, Tristan A. Reekie, Anna Herman-Antosiewicz   +7 more
doaj   +1 more source

Effect of endophyte infection on chlorophyll a fluorescence in salinity stressed rice

Biologia Plantarum, 2014
We have earlier reported that the endophyte infection can enhance photosynthetic capacity and antioxidant enzyme activities in rice exposed to salinity stress.
X. M. Li, M. J. Chen, J. Li, L. J. Ma, N. Bu, Y. Y. Li, L. H. Zhang   +6 more
doaj   +1 more source

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

International Journal of Molecular Medicine, 2019
The mammalian mitochondrial electron transport chain (ETC) includes complexes I-IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and ...
Ruzhou Zhao, Shuai Jiang, Lin Zhang, Zhi-Bin Yu   +3 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Complex I and II Subunit Gene Duplications Provide Increased Fitness to Worms

Frontiers in Genetics, 2019
Helminths use an alternative mitochondrial electron transport chain (ETC) under hypoxic conditions, such as those found in the gastrointestinal tract.
Lucía Otero, Cecilia Martínez-Rosales, Exequiel Barrera, Sergio Pantano, Gustavo Salinas   +4 more
doaj   +1 more source

Mitochondrial function and Aβ in Alzheimer's disease postmortem brain

Neurobiology of Disease, 2022
Introduction: Mitochondrial dysfunction is observed in Alzheimer's disease (AD). However, the relationship between functional mitochondrial deficits and AD pathologies is not well established in human subjects.
Benjamin R. Troutwine, Taylor A. Strope, Edziu Franczak, Colton R. Lysaker, Laylan Hamid, Clayton Mansel, Julia A. Stopperan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins   +10 more
doaj   +1 more source