Results 71 to 80 of about 605,158 (291)

Mitochondrial Handling of Excess Ca\u3csup\u3e2+\u3c/sup\u3e is Substrate-dependent with Implications for Reactive Oxygen Species Generation [PDF]

, 2013
The mitochondrial electron transport chain is the major source of reactive oxygen species (ROS) during cardiac ischemia. Several mechanisms modulate ROS production; one is mitochondrial Ca2+ uptake.
Aldakkak, Mohammed, Camara, Amadou K.S., Dash, Ranjan K., Stowe, David F.   +3 more
core   +1 more source

Wide-field Magnetic Field and Temperature Imaging using Nanoscale Quantum Sensors

, 2019
The simultaneous imaging of magnetic fields and temperature (MT) is important in a range of applications, including studies of carrier transport, solid-state material dynamics, and semiconductor device characterization.
Bagnall, Kevin R., Englund, Dirk R., Foy, Christopher, Trusheim, Matthew E., Walsh, Michael, Wang, Evelyn N., Zhang, Lenan   +6 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Mitochondrial function in Antarctic nototheniids with ND6 translocation.

PLoS ONE, 2012
Fish of the suborder Notothenioidei have successfully radiated into the Southern Ocean and today comprise the dominant fish sub-order in Antarctic waters in terms of biomass and species abundance. During evolution in the cold and stable Antarctic climate,
Felix C Mark, Magnus Lucassen, Anneli Strobel, Esteban Barrera-Oro, Nils Koschnick, Lorenzo Zane, Tomaso Patarnello, Hans O Pörtner, Chiara Papetti   +8 more
doaj   +1 more source

Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells [PDF]

, 2006
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2-regulated K+ channels. The mechanisms involved in the detection of changes of O2 tension are unknown.
García Fernández, María, López Barneo, José, Ortega Sáenz, Patricia, Piruat Palomo, José Ignacio   +3 more
core  

Structure of a bacterial cell surface decaheme electron conduit [PDF]

, 2011
Some bacterial species are able to utilize extracellular mineral forms of iron and manganese as respiratory electron acceptors. In Shewanella oneidensis this involves decaheme cytochromes that are located on the bacterial cell surface at the termini of ...
A. Hall, A. J. Gates, A. S. Beliaev, Adams, Bucking, C. L. Reardon, Collaborative Computational Project Number, D. J. Richardson, Einsle, Emsley, Field, Firer-Sherwood, G. F. White, Hartshorne, Igarashi, J. Bradley, J. K. Fredrickson, J. M. Zachara, J. N. Butt, Johs, L. Shi, Lies, M. J. Edwards, M. J. Marshall, McCoy, McLean, N. J. Watmough, Porollo, Ries, Ruebush, Sheldrick, Shi, Shi, T. A. Clarke, Z. Wang   +34 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration.

Frontiers in Oncology, 2012
Pyrvinium pamoate (PP) is an FDA-approved classical anthelmintic, but is now attracting particular attention as an anti-cancer drug after recent findings of its potent cytotoxicity against various cancer cell lines only during glucose starvation, as well
Isao eIshii, Yasuo eHarada, Tadashi eKasahara   +2 more
doaj   +1 more source

The effect of nicosulfuron and bentazon on photosynthetic performance of common cocklebur (Xanthium strumarium L.)

Environmental and Sustainability Indicators, 2020
In order to evaluate the effects of bentazon and nicosulfuron on the photosynthetic apparatus of X. strumarium in greenhouse condition, chlorophyll a fluorescence (ChlF) method was studied at 1, 2, 3, and 4 days after herbicide treatment (DAHT). Bentazon
Sirous Hassannejad, Soheila Porheidar Ghafarbi, Ramin Lotfi   +2 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source