Results 51 to 60 of about 405,671 (240)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development of a Web-Based Electronic Data Capture Monitoring System Using the PIECES and Waterfall Models

Jurnal Abdimas Cendekiawan Indonesia
The development of digital transactions has driven the need for more accurate and easily monitored Electronic Data Capture (EDC) devices to support payment processes in the retail and distribution sectors.
Akbar Iskandar, Vitara Aji Bimantara, Kamaruddin Kamaruddin, Riska Kherani, Kavya Patel, Erwin Gatot Amiruddin, Bobur Sobirov   +6 more
doaj   +1 more source

Assessment of select electronic health information systems that support immunization data capture – Kenya, 2017

BMC Health Services Research, 2018
Background Although electronic health information systems (EHIS) with immunization components exist in Kenya, questions and concerns remain about their use and alignment with the Kenya Ministry of Health’s (MOH) National Vaccine and Immunization Program (
Apophia Namageyo-Funa, Millicent Aketch, Collins Tabu, Adam MacNeil, Peter Bloland   +4 more
doaj   +1 more source

Assessment of the Chad guinea worm surveillance information system: A pivotal foundation for eradication.

PLoS Neglected Tropical Diseases, 2021
BackgroundIn the absence of a vaccine or pharmacological treatment, prevention and control of Guinea worm disease is dependent on timely identification and containment of cases to interrupt transmission.
Saugat Karki, Adam Weiss, Jina Dcruz, Dorothy Hunt, Brandon Haigood, Philip Tchindebet Ouakou, Elisabeth Chop, Hubert Zirimwabagabo, Beth L Rubenstein, Sarah Yerian, Sharon L Roy, Mary L Kamb, Sarah Anne J Guagliardo   +12 more
doaj   +1 more source

Procurement of shared data instruments for Research Electronic Data Capture (REDCap)

Journal of Biomedical Informatics, 2013
REDCap (Research Electronic Data Capture) is a web-based software solution and tool set that allows biomedical researchers to create secure online forms for data capture, management and analysis with minimal effort and training. The Shared Data Instrument Library (SDIL) is a relatively new component of REDCap that allows sharing of commonly used data ...
Jihad S. Obeid, Catherine A. McGraw, Brenda L. Minor, Jose G. Conde, Robert Pawluk, Michael Lin, Janey Wang, Sean R. Banks, Sheree A. Hemphill, Robert Taylor 0001, Paul A. Harris   +10 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

REDCapDM: An R package with a set of data management tools for a REDCap project

BMC Medical Research Methodology
Background Research Electronic Data CAPture (REDCap) is a web application for creating and managing online surveys and databases. Clinical data management is an essential process before performing any statistical analysis to ensure the quality and ...
João Carmezim, Pau Satorra, Judith Peñafiel, Esther García-Lerma, Natàlia Pallarès, Naiara Santos, Cristian Tebé   +6 more
doaj   +1 more source

Electronic Data Capture-Selecting an EDC System

Journal of the Society for Clinical Data Management, 2021
Web-based Electronic data capture (EDC) has become the preferred method for capture of key-entered data in clinical studies. This chapter reviews the considerations for selecting an EDC system including evaluation of systems and vendors, user requirements, an process change, as well as initial implementation of systems within organizations. The goal of
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source