Results 61 to 70 of about 1,258,594 (266)

Participant experiences in a decentralized clinical trial using digital health technologies: The ACTIV-6 study

Journal of Clinical and Translational Science
Background: Inadequate recruitment and retention impede clinical trial goals. Emerging decentralized clinical trials (DCTs) leveraging digital health technologies (DHTs) for remote recruitment and data collection aim to address barriers to participation ...
Carrie Reale, Janelle Faiman, Russ Beebe, Jessica S. Marlin, Sean Collins, David R. Boulware, Sarah E. Dunsmore, Florence Thicklin, Thomas G. Stewart, Adrian F. Hernandez, Russell L. Rothman, Christopher J. Lindsell, Shilo Anders, for the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)-6 Study Group and Investigators   +13 more
doaj   +1 more source

Review of developments in electronic, clinical data collection and documentation systems over the last decade – Are we ready for Big Data in routine health care?

Frontiers in Oncology, 2016
Recently, information availability has become more elaborate and wide spread, and treatment decisions are based on a multitude of factors including imaging, molecular or pathological markers, surgical results and patient’s preference. In this context the
Kerstin Anne Kessel, Kerstin Anne Kessel, Stephanie E Combs, Stephanie E Combs   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Human resource requirements for quality-assured electronic data capture of the tuberculosis case register

BMC Research Notes, 2012
Background The tuberculosis case register is the data source for the reports submitted by basic management units to the national tuberculosis program. Our objective was to measure the data entry time required to complete and double-enter one record, and ...
Hoa Nguyen B, Sokun Chay, Wei Chen, Lauritsen Jens M, Rieder Hans L   +4 more
doaj   +1 more source

Collisions of Slow Highly Charged Ions with Surfaces [PDF]

, 2006
Progress in the study of collisions of multiply charged ions with surfaces is reviewed with the help of a few recent examples. They range from fundamental quasi-one electron processes to highly complex ablation and material modification processes.
Burgdörfer, J., Lemell, C., okési, K. T\H, Reinhold, C., Schiessl, K., Solleder, B., Wirtz, L.   +6 more
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Collaborative compliance: A consortium-based framework for achieving 21 CFR part 11 readiness in REDCap across CTSA institutions

Journal of Clinical and Translational Science
Academic research institutions using REDCap often face challenges aligning with U.S. FDA requirements for electronic records and signatures under 21 CFR Part 11 (Part 11).
Theresa Baker, Teresa Bosler, April Green, Jason Lones, Katie Keenoy, Bridget Adams, Bas de Veer, Brian Bush, Stephanie Oppenheimer, Sheree Hemphill, Elinora Price, Haley Neese, Ashley Tippett, Audrey Perdew, Randy Madsen, Catherine Bauer-Martinez, Robert Bradford, Paul Harris, Alex Cheng   +18 more
doaj   +1 more source

Assessment of the Chad guinea worm surveillance information system: A pivotal foundation for eradication.

PLoS Neglected Tropical Diseases, 2021
BackgroundIn the absence of a vaccine or pharmacological treatment, prevention and control of Guinea worm disease is dependent on timely identification and containment of cases to interrupt transmission.
Saugat Karki, Adam Weiss, Jina Dcruz, Dorothy Hunt, Brandon Haigood, Philip Tchindebet Ouakou, Elisabeth Chop, Hubert Zirimwabagabo, Beth L Rubenstein, Sarah Yerian, Sharon L Roy, Mary L Kamb, Sarah Anne J Guagliardo   +12 more
doaj   +1 more source