Results 41 to 50 of about 9,832,702 (268)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Cogent Social SciencesAssessing the state of the mapping level and prospects for digitalization of public administration in the global economy over the past 40 years through the implementation of bibliometric analysis.
Sholpan Smagulova +3 more
doaj +1 more source
Социологическая наука и социальная практика, 2019 This is the first part of an article that will discuss digital transformation issues in Russian regions that differ by social and cultural modernization level, as well as the population’s willingness to accept digital transformation in life and at work ...
Vladimir S. Bogdanov
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
New service development in e-government: identifying critical success factors [PDF]
, 2010 Purpose: The purpose of this paper is to suggest a model that incorporates critical factors contributing to the success in new service development (NSD) projects in electronic government (e-government).
Kitsios, Fotis +5 more
core +1 more source
T.C. Sağlık Bakanlığı’nın Mobil Sağlık Uygulamalarının Bilinirliğine Yönelik Bir Araştırma
SDÜ Vizyoner Dergisi, 2022 Günümüz mobil sağlık pazarı incelendiğinde her yaşa ve ihtiyaca göre geliştirilen uygulamalar bulunabilmektedir. Mevcut bu çalışma kapsamında değişime ve gelişime ayak uyduran T.C. Sağlık Bakanlığı’nın vatandaşlar için geliştirdiği m-Sağlık uygulamaların
Elif Nisa Yayla, Bülent Çizmeci
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Electronic Service Quality in Public Sector Case of Raja Company [PDF]
Journal of Information Technology Management, 2009 The paper reveals the findings of a case study in "Raja Passenger Trains Company". This company has been established in 1996 and is affiliated to the Railways of Islamic Republic of Iran.
شمسالسّادات زاهدی +1 more
doaj
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source