Results 131 to 140 of about 2,528,291 (336)

Solid waste management practices and challenges in Besisahar municipality, Nepal.

PLoS ONE
This study is a comprehensive assessment of the waste management system in Besisahar municipality. Information and some data have been collected from the municipality of Besisahar, followed by interviews with municipal officials responsible for waste ...
Mahendra Aryal, Sanju Adhikary
doaj   +1 more source

Strategic Alignment Gap Diagnosis between Information Technology Strategies and the Organizational Strategies in Esfahan Municipality [PDF]

مطالعات مدیریت راهبردی, 2011
The current paper is trying to study the pathology of strategic alignment gap between Information Technology strategies and the organizational strategies in the following four areas: 1) Management and leadership through three indices of Governance ...
Ali Attafar, Nematallah Akbari, Olfat Ganji   +2 more
doaj  

Receivership : a coordinated strategy to stabilize troubled properties [PDF]

With the impact of municipal debt burdens, coupled with the effects of declining real estate prices and the US financial crisis, municipalities are looking for novel and cost-effective approaches to address abandoned, blighted and/or foreclosed ...
Chris Edell, Kai-yan Lee
core  

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Electronic Bidding and Efficiency in the Municipal Public Spending

, 2014
Com a busca de maior transparência no setor público, o pregão eletrônico passou a ser amplamente discutido nas esferas municipais, como forma de proporcionar maior eficiência, transparência, economicidade e celeridade nas compras públicas. Nessa perspectiva, este estudo tem como objetivo identificar as contribuições do pregão eletrônico para a ...
Ferreira, Marco Aurélio Marques, Medina, Silvana Aparecida, Reis, Anderson de Oliveira   +2 more
openaire   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

The experiences of the introduction and application of the Municipality ASP system

Köz-gazdaság, 2019
The thought of the nationwide introduction of the Municipality ASP system (hereafter: ASP) emerged in 2014 as a governmental objective. Between 2015 and 2019 - with the exception of the capital - every local government joined the ASP, which now has ...
Erika Kócsáné Horváth, Eszter Halász   +1 more
doaj  

Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal‐Immunotherapy

Advanced Science, EarlyView.
Liposomal nanoconfinement converts the hemicyanine photosensitizer RhM from Type‐II to Type‐I photodynamic therapy (PDT) while enhancing photothermal therapy (PTT). The RhM‐R837@Lip nanoassembly efficiently generates superoxide (O2•−) and hydroxyl radicals (•OH) to kill tumor cells and achieve tumor ablation.
Minglu Zhang, Shanshan Liang, Meng Wang, Tingfeng Zhang, Jinke Liu, Yuyuan Peng, Hao Fang, Lingna Zheng, Xiao He, Meng Wang, Luling Wu, Tony D. James, Wei Zhao, Bing Wang, Weiyue Feng   +14 more
wiley   +1 more source