Results 231 to 240 of about 2,528,291 (336)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Small-Area Lung Cancer Incidence and Mortality: Cross-Sectional Population-Based Study Using Hospital Discharge and Death Registration Data. [PDF]

JMIR Public Health Surveill
He Y, Xia X, Wang Q, Zhang Y, Meng Y, Ji X, Zhao Q, Wang Y, Zhao Y, Xue F, Xu J.   +10 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Evidence of a two-dimensional nitrogen crystalline structure on silver surfaces. [PDF]

Nat Commun
Hu X, Cao H, Gao Z, Zhou H, Geng D, Li D, Gao J, Zhao Q, Cai Z, Cheng P, Chen L, Meng S, Wu K, Feng B.   +13 more
europepmc   +1 more source

Implementing Electronic Participatory Budgeting in Swedish Municipalities

Publikationer från Örebro universitet, 2010
openaire   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source

Response of the authors to the letter to the editor regarding "Development of a machine learning-based predictive model for long-term adverse outcomes in neonatal bacterial meningitis". [PDF]

J Pediatr (Rio J)
Chen Y, Wang S, Wu J, Wang C, Li Y, Zou P, Xiao R, Zhang N, He H, Wang Y.   +9 more
europepmc   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

The Municipal Sustainable Development Health Index (MSDHI) to monitor the 2030 agenda in Brazil: a methodological proposal. [PDF]

Int J Equity Health
Fernandes LDMM, Marinho CV, Jardim LL, Rodrigues IB, Paes-Sousa R.   +4 more
europepmc   +1 more source

The Municipality, Section 1983 and Pendent Jurisdiction [PDF]

, 2011

core   +1 more source