Results 131 to 140 of about 435,606 (297)
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Emergence of immediate funds transfer as a general-purpose means of payment [PDF]
Immediate funds transfer (IFT) is a highly convenient, certain, secure, and economical means of payment using bank money. IFT is not available in the U.S.
Bruce J. Summers, Kirstin E. Wells
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Openness and technology diffusion in payment : the case of NAFTA [PDF]
, 2012 We study the relationship between openness and payment system development. In particular, we analyze how the existence of technology diffusion from a more developed country fosters a transformation of payment choice in a less developed country.
Callado, Francisco +3 more
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Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS
Advanced Science, EarlyView.ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi +4 more
wiley +1 more source
An Economic Analysis of the Single Euro Payments Area (SEPA) [PDF]
Under which conditions is it advantageous for countries to form a single payments area? This question is analyzed in a model of spatial bank competition to understand better the economic foundations of the Single Euro Payments Area (SEPA).
Guido K. Schaefer
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Advanced Science, EarlyView.ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo +13 more
wiley +1 more source
Payment systems in Latin America : a tale of two countries - Colombia and El Salvador [PDF]
Payment systems include all the paper (including cash) and electronic systems a country uses to exchange financial value to discharge obligations. Financial markets rely on promptness and certainty of payment and settlement for borrowing and investing ...
Listfield, Robert +1 more
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Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
The Federal Reserve's role in the payments mechanism and it's communication patterns [PDF]
An abstract for this article is not available.Federal Reserve System ; Electronic funds transfers ; Payment ...
Theodore E. Allison
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