Results 21 to 30 of about 631,952 (258)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The Study of Analytical Model of Library Electronic Resources Usage-A Case of Medical Electronic Resources [PDF]
Jiàoyù zīliào yǔ túshūguǎn xué, 2014 With the advents of internet, the importance of electronic resources is growing. Due to the increasing expensiveness of electronic resources, university libraries normally received budgets from parent institutions annually.
Chung-Yen Yu, Jiann-Cherng Shieh
doaj +1 more source
Licensing Electronic Resources [PDF]
The Serials Librarian, 2002 Abstract The presenter covered the licensing process and the wide range of tasks and issues it comprises: pre-negotiations, team approaches to license negotiation, users and uses, negotiating strategies, online resources, understanding the license, and specialized topics such as copyright, shrink wrap licenses, and UCITA.
Laurie Thompson, Sandhya D. Srivastava
openaire +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Opportunities and Risks of Distance Format in Music Learning to Schoolchildren [PDF]
Музыкальное искусство и образование, 2020 The article is devoted to the analysis of the forms and methods of music learning to schoolchildren during the self-isolation period. Distance learning is viewed in the context of new trends, opportunities and risks in relation to the various ...
Nelly V. Suslova
doaj +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Student attitudes towards electronic information resources
Information Research: An International Electronic Journal, 1998 Students are increasingly expected to use electronic resources while at university. Studies were undertaken to determine the level of use of this type of resource, how students feel about various issues surrounding electronic resources and whether ...
Kathryn Ray, Joan Day
doaj
The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley +1 more source