Results 41 to 50 of about 1,006 (259)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Robust flatness-based switching reconfiguration control using state flow machines of electronic throttle valve

MATEC Web of Conferences, 2016
In this paper, a robust Fault Tolerant Control reconfiguration approach using State Flow Machines is proposed. Indeed, this reconfiguration strategy is based on robust flatness-based switching control using state machines and flow charts.
Gharsallaoui Hajer, Gritli Wafa, Benrejeb Mohamed   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

基于分段线性控制策略的回流式无级变速器起步仿真研究

Jixie chuandong, 2014
The dynamical model is established based on the analysis for starting process of continuously variable transmission system with reflux power.To achieve the goal of constant engine speed starting control,the target control table on the changing rate of ...
尹燕莉, 邓涛, 秦松涛, 潘小亮, 丁建明, 赵双   +5 more
doaj  

Title Discrete-Time Fast Terminal Sliding Mode Control Based on Generalized Implicit Reaching Law for Electronic Throttle

Machines
To achieve precise tracking control under the hardware of electronic throttle digital control, this paper proposes a novel implicit discrete-time fast terminal sliding mode control method for electronic throttles.
Wenjiang Zhu, Jie Zhang, Yinhui Yu, Wenqian Liu   +3 more
doaj   +1 more source

Model-Based Throttle Control using Static Compensators and Pole Placement Commande des gaz basée sur un modèle utilisant des compensateurs statiques et un placement de pôles

Oil & Gas Science and Technology, 2011
In modern spark ignited engines, the throttle is controlled by the Electronic Control Unit (ECU), which gives the ECU direct control of the air flow and thereby the engine torque.
Thomasson A., Eriksson L.
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Study on the Emission of Connected Autonomous Vehicle Considering the Control of Electronic Throttle Opening

World Electric Vehicle Journal
Aiming at the networked cruise control scenario of CAV (connected autonomous vehicle) queue, we propose a new networked cruise control strategy for CAV by introducing the average information of ET (electronic throttle) opening of the downstream vehicle ...
Yirong Kang, Chuan Tian
doaj   +1 more source