Results 51 to 60 of about 6,790,518 (151)

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Autonomous X‐Ray Fluorescence Mapping for Nanoscale Chemical Speciation of Fine Particulate Matter

Advanced Intelligent Discovery, EarlyView.
We present X‐AutoMap, an autonomous X‐ray fluorescence mapping framework that integrates real‐time analysis with rule‐based computer vision to selectively target chemically relevant regions. By avoiding background‐dominated areas, the method reduces acquisition time by fourfold while enabling accurate particle‐level speciation.
Carlos Deleon, Dmitri Gavrilov, Peggy O’Day, Ajith Pattammattel   +3 more
wiley   +1 more source

Modelling and simulation of electronic wedge brake based antilock brake system [PDF]

, 2019
This paper discusses the modelling and validation of Electronic Wedge Brake (EWB) based Antilock Brake System (ABS) for typical vehicle. The EWB was use as brake actuator while quarter car vehicle is select to establish ABS.
Che Hasan, Mohd Hanif, Ahmad, Fauzi, Hassan, Mohd Khair   +2 more
core   +1 more source

Study of Mechanism for Wear Adjustment with Electro Wedge Brake

, 2014
Electro wedge brake (EWB) have been suggested and improved for enhancing the braking efficiency and reducing the weight and power of actuating motor than electro mechanical brake (EMB).
Dong-Hwan Shin, T. Park, Sung-Ho Jin, J. Moon, Seung-Han Yang   +4 more
semanticscholar   +1 more source

Triboelectric nanogenerators for vehicle intelligent cockpits

FlexMat, EarlyView.
Converting mechanical stimuli from drivers and vehicle motion into electrical signals, triboelectric nanogenerators provide promising interfaces toward passive, flexible, distributed and intelligent sensing for next‐generation automotive cockpits to support three core functional dimensions: driver state monitoring, vehicle state monitoring, and human ...
Haiqiu Tan, Shiquan Lü, Xiangwei Meng, Huiying Zhang, Wenxing Zhang, Dongxian Sun, Xiao Lu, Lei Wang, Haodong Zhang, William W. Yu   +9 more
wiley   +1 more source

An electrothermal platform for active droplet manipulation. [PDF]

RSC Adv, 2023
Liu Y, Xia Y, Zhan H, Lu C, Yuan Z, Zhao L.   +5 more
europepmc   +1 more source

Characteristics, properties and limitations of per‐ or polyfluoroalkyl substances (PFASs) and fluoropolymers

Polymer International, EarlyView.
An overview and categorization of man‐made per‐ or polyfluoroalkyl substances (PFASs) including low‐molar‐mass and high‐molar‐mass fluorochemicals, and their international regulations is presented. Though certain PFASs are toxic, bioaccumulative and cross the human cellular membranes, others, such as fluoropolymers, are safe, reliable and involved in ...
Bruno Améduri
wiley   +1 more source

A computational fluid dynamic analysis on the effect of front row pin geometry on the aerothermodynamic properties of a pin-vented brake disc [PDF]

, 2008
Increasing demand from the consumer for higher levels of refinement from their passenger vehicles has put considerable pressure on the automotive industry to produce ever quieter cars.
Palmer, E., Fieldhouse, J., Palmer, Edward, Fieldhouse, John D., Mishra, R., Mishra, Rakesh   +5 more
core   +1 more source