Results 201 to 210 of about 63,842 (308)

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

TLR4 Induces PANoptosis in Annulus Fibrosus Cells by Activating NLRP12 in Intervertebral Disc Degeneration. [PDF]

J Inflamm Res
Zheng F, Cao L, Fu J, Luo M, Yue W, Ma Y, Chen B, Zhai Y, Liu C.   +8 more
europepmc   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Transcriptomic insights into the anti-apoptotic effect of Tuina in rabbit model of intervertebral disc degeneration. [PDF]

J Orthop Surg Res
Ye J, Zhu J, Kuang K, Li Y, Su C.
europepmc   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single-Cell Sequencing Analysis. [PDF]

Mediators Inflamm
Liu C, Jiao K, Li X, Deng Z, Wang S, Cheng Y, Li M, Zhou X, Wei X.   +8 more
europepmc   +1 more source

Isolation of Phospholipase A2 from Agkistrodon bilineatus Venom [PDF]

, 1980
Johnson, Bob D., Landberg, Karl H., Sifford, Dewey H.   +2 more
core   +2 more sources

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Investigation of the Abundance of Escherichia coli and Staphylococcus aureus (Including Virulence Gene Profiles) and Heavy Metal Contamination in Camel Milk. [PDF]

Vet Med Sci
Ghahfarokhi EY, Shakerian A, Chaleshtori RS, Rahimi E.   +3 more
europepmc   +1 more source