ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Minigenes for heterologous expression of human and mouse cationic trypsinogen. [PDF]
Berke G, Sahin-Tóth M.
europepmc +1 more source
FXTAS and the Spectrum of FMR1 Premutation‐Associated Phenotypes in Latin America: A Scoping Review
Abstract Background Fragile X–associated tremor/ataxia syndrome (FXTAS) is a late‐onset neurodegenerative disorder caused by FMR1 premutation expansions (55–200 CGG repeats). Although well described in populations of predominantly European ancestry, FXTAS remains poorly characterized in Latin America due to limited awareness, restricted access to ...
Amy Schmidmajer +6 more
wiley +1 more source
Optical biosensing using particle diffusometry on thermoplastic microfluidic chips bonded using direct and indirect chip bonding methods. [PDF]
Rivera-De Jesus JA +6 more
europepmc +1 more source
A Case Report of a Special Type of Multiple Myeloma: Kappa Light Chain‐Only
This case illustrates the clinical course of a patient diagnosed with kappa light chain‐only multiple myeloma, a rare subtype of multiple myeloma. Of note, light chain multiple myeloma is characterized by rapid disease progression and severe target organ damage.
Yanhua Dai +8 more
wiley +1 more source
A novel HBD gene mutation associated with normal-range hb A2 in β-thalassemia carriers. [PDF]
Zhang L +8 more
europepmc +1 more source
Through experimental design, polylactic acid (PLA)—organoclay dispersions were optimized to produce biobased coatings that have a high barrier potential while maintaining repulpability, promoting sustainable packaging solutions. ABSTRACT Performance and recyclability of paper coatings depend on precise control of polymer, surfactant, filler ...
Abdenour Chenni +7 more
wiley +1 more source
Biosurfactant was produced by Pseudomonas aeruginosa using andiroba waste from Amazonia. A biosurfactant–alginate composite (Alg/BioS) was successfully synthesized via ionotropic gelation, and achieved up to 70% Cr6+ removal from water. Abstract Environmental contamination by heavy metals represents a significant challenge due to their persistence in ...
Paulo Diniz Austriaco +11 more
wiley +1 more source
Migration of Plastic Additives and Non-Intentionally Added Substances from Packaging into Edible Oils and Beverages: A Combined GC-MS and Hydrolysis-Capillary Electrophoresis Approach. [PDF]
Sturza R +5 more
europepmc +1 more source
Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan +5 more
wiley +1 more source

