Results 171 to 180 of about 336,912 (248)

Clear Native Gel Electrophoresis for the Purification of Fluorescently Labeled Membrane Proteins in Native Nanodiscs

Ezsias B, Goessweiner-Mohr N, Siligan C, Horner A, Vargas C, Keller S, Pohl P.   +6 more
europepmc   +1 more source

The two-component system CpxAR controls biofilm formation by directly regulating the T3SS needle tip protein EseB in <i>Edwardsiella piscicida</i>. [PDF]

Appl Environ Microbiol
Zhang SY, Sun SS, Liu LY, Sivaranjan T, Nie P, Xie HX.   +5 more
europepmc   +1 more source

Copper‐Based Nanotubes That Enhance Starvation Therapy Through Cuproptosis for Synergistic Cancer Treatment

Advanced Science, EarlyView.
We designed a copper‐based nanotube (NT) with copper ionophores to induce enhanced cuproptosis. In combination with starvation therapy, the NT significantly inhibited energy metabolism in HCC cells. Our results show that the depletion of GSH by Cu2+ intensified oxidative stress and cuproptosis, resulting in ROS generation and DLAT aggregation ...
Xuan Han, Xin Zhang, Zhiping Liu, Hang Liu, Derek Wu, Yinli He, Kexin Yuan, Yi Lyu, Xiaofei Liu   +8 more
wiley   +1 more source

Teichoic acids in the periplasm and cell envelope of <i>Streptococcus pneumoniae</i>. [PDF]

Elife
Nguyen M, Bauda E, Boyat C, Laguri C, Freton C, Chouquet A, Gallet B, Baudoin M, Wong YS, Grangeasse C, Moriscot C, Durmort C, Zapun A, Morlot C.   +13 more
europepmc   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Isolation, biochemical characterization, and primary structure and active site determination of <i>Dioscorea opposita</i> ('Nagaimo') oligopeptidase B. [PDF]

Biochem Biophys Rep
Miyazaki-Katamura S, Chosei M, Tate S, Sakaue T, Yamane T, Suzuki J, Higashiyama S, Ohkubo I.   +7 more
europepmc   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Optimizing Bay Scallop (<i>Argopecten irradians</i>) Product Quality: Moderate Freezing as an Effective Strategy for Improving Adductor Muscle Gel Properties. [PDF]

Foods
Chang K, Lin Y, Huang S, Fan X, Ma Y, Li M, Zhao Q.   +6 more
europepmc   +1 more source

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

Visualization of protrusion-localized STAT3 mRNA using a self-powered lipidic nanoflare for predicting hepatocellular carcinoma metastasis. [PDF]

Mikrochim Acta
Zhang Y, Zeng R, Xia Y, Han W, Luan Y, Zhang Y, Wu S, Wang S, Wang J, Chen Y, Chen D.   +10 more
europepmc   +1 more source