The therapeutic efficacy of lipid nanoparticle(LNP)‐based drugs depends on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying the endosomal escape efficiency index using magnetic resonance imaging is introduced.
Somin Lee +5 more
wiley +1 more source
First report of 16SrII-A phytoplasma associated with witches' broom in <i>Heliotropium arboreum</i> (Blanco) Mabb. from Xisha Islands, with <i>Halticus minutus</i> as a putative vector. [PDF]
Wang B +5 more
europepmc +1 more source
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology.
S. Gygi +4 more
semanticscholar +1 more source
Progressive Insights into 3D Bioprinting for Corneal Tissue Restoration
This review explores the potential of 3D bioprinting to replicate the complex structure and function of the human cornea. It highlights key advances in bioink development, printing modalities, and in vivo performance, while addressing current challenges and emerging strategies. The review emphasizes bioprinting's promise to overcome donor shortages and
Ilayda Namli +6 more
wiley +1 more source
Rapid and Visually Specific Detection of <i>Sarcocystis miescheriana</i> and <i>Sarcocystis suihominis</i> Infections in Domestic Pigs (<i>Sus scrofa domesticus</i>) Using Loop-Mediated Isothermal Amplification. [PDF]
Hu Z +7 more
europepmc +1 more source
Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu +8 more
wiley +1 more source
An innovative full-size pathogenic tandem duplication mutation precise detection system based on next-generation sequencing. [PDF]
Zhang LL +7 more
europepmc +1 more source
DIFFERENTIAL TITRATION BY MEANS OF PAPER ELECTROPHORESIS AND THE STRUCTURE OF HUMAN HEMOGLOBINS
I. Herbert Scheinberg +2 more
openalex +1 more source

