Results 101 to 110 of about 4,599 (236)

Deep Brain Stimulation after Subthalamic Focused Ultrasound for Parkinson's Disease

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Ayaka Ichise   +10 more
wiley   +1 more source

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder   +7 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock   +9 more
wiley   +1 more source

Reprocessing of Medical Products in Electrophysiology

open access: yesArquivos Brasileiros de Cardiologia
Ricardo Ryoshim Kuniyoshi   +3 more
doaj   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

Atrial Flutter Secondary to Severe Laxative-Induced Hypomagnesemia in Anorexia Nervosa: A Case Report. [PDF]

open access: yesCureus
Patibandla S   +6 more
europepmc   +1 more source

Large Language Model‐Based Localization of Premature Ventricular Contraction Origins: A Retrospective Diagnostic Accuracy Study

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Accurate localization of premature ventricular contraction (PVC) origin from 12‐lead electrocardiography (ECG) is important for procedural planning in catheter ablation. Although convolutional neural network (CNN)‐based models have shown promising diagnostic performance, they require task‐specific training and remain limited in ...
Kazuhisa Matsumoto   +12 more
wiley   +1 more source

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