Results 71 to 80 of about 4,347 (234)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Cardiac MIBG Scintigraphy in Neurodegenerative Parkinsonism: Limitations in Clinical Practice

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Reduced cardiac uptake on 123Iodine‐metaiodobenzylguanidine (MIBG) scintigraphy is a valuable tool for differentiating neurodegenerative parkinsonism but interpretation can be difficult due to comorbidities and drug‐tracer interactions.
Frank Jagusch, Elena Redl, Christoph Theyer, Atbin Djamshidian, Alessandra Fanciulli, Werner Poewe, Philipp Mahlknecht, Beatrice Heim, Klaus Seppi, Florian Krismer   +9 more
wiley   +1 more source

Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Stiff person syndrome (SPS) is a rare disabling neurological condition with overlapping symptomatology with more common neurological conditions. Exaggerated exteroceptive reflex mechanisms are thought to play a role in its pathophysiology.
Belinda Cruse, Duncan Wilson, Hugo Morales Briceno, Pamela Garcia, Victor Zhang, Jessica Qiu, Tomas Kalincik, Neil Mahant, Victor Shue Chung Fung   +8 more
wiley   +1 more source

Protocol to study electrophysiological properties of hPSC-derived 3D cardiac organoids using MEA and sharp electrode techniques

STAR Protocols
Continuing advancements in human pluripotent stem cell (hPSC)-derived complex three-dimensional (3D) cardiac tissues require the development of novel technologies or adaptation of existing technologies to understand the physiology of the derived 3D cardiac tissues.
Ravichandra Venkateshappa, Zehra Yildirim, Shane R. Zhao, Matthew A. Wu, Francesca Vacante, Oscar J. Abilez, Joseph C. Wu   +6 more
openaire   +3 more sources

The Application of Telemedicine in Surgery

Med Research, EarlyView.
This figure provides an overview of the content presented in this article. Telemedicine is integrated throughout the entire surgical workflow, with distinct applications across the preoperative, intraoperative, and postoperative phases. These applications are enabled by a suite of supporting technologies, while the associated implementation challenges ...
Yufan Yang, Chang Liu, Xue Sun, Yiting Wang, Minghui Zhao, Shuya Jiang, Haoling Zhang, Wangzheqi Zhang, Wenwen Shi   +8 more
wiley   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Adaptive Pudendal Nerve Stimulation: A Pilot Study on Safety, Technical Feasibility, and Clinical Effect

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To evaluate the safety, procedural feasibility, and pilot clinical outcomes for a new implanted device delivering adaptive pudendal nerve stimulation. Materials and Methods Thirteen adult women with treatment‐refractory mixed (n = 8) or urge (n = 5) urinary incontinence were implanted with a Picostim‐DyNeuMo system incorporating an ...
Siemen Herroelen, Charles H. Knowles, Sean Doherty, Mo Benjaber, Jacob Kerr, Karen Wendt, Aidan Crawley, Tim Denison, Stefan De Wachter   +8 more
wiley   +1 more source

Behavioural manipulation of the cabbage stem flea beetle (Psylliodes chrysocephala L): Prospects for push–pull strategies in oilseed rape

Pest Management Science, EarlyView.
Behavioural manipulation of Psylliodes chrysocephala provides promising opportunities for sustainable pest management in oilseed rape systems. This review synthesises evidence on glucosinolates and their volatile isothiocyanate derivatives as phagostimulants and attractants, alongside the repellent or antifeedant effects of non‐host plants, plant ...
Suleiman Mustapha, Patricia A Ortega‐Ramos, Jozsef Vuts, Tariq M Butt, E. Joel Loveridge, Daniel Rüde, Samantha M Cook   +6 more
wiley   +1 more source

Update on the Pathophysiology, Aetiology and Management of Central Sleep Apnoea

Respirology, EarlyView.
ABSTRACT Central sleep apnoea (CSA) of the periodic breathing type occurs during the transition between wakefulness and stage 1 and 2 non‐REM sleep. In adults at sea level, it occurs most commonly due to advanced heart failure (HF) or chronic opioid use and in ~5% of obstructive sleep apnoea patients initiating CPAP.
Sahan D. Chandrasekara, Matthew T. Naughton   +1 more
wiley   +1 more source

Artificial intelligence in out‐of‐hospital sleep monitoring: Bridging polysomnography and wearable signals

Sleep Research, EarlyView.
Abstract Polysomnography (PSG), the reference standard for sleep assessment, has limited scalability for large‐scale screening, driving the development of wearable and unobtrusive monitors. However, the physiological signals these devices capture are physiologically correlated with PSG channels but are not completely equivalent.
Jing Yan, Zixi Huang, Haowen Zeng, Hanrong Cheng, Dongxing Zhao, Yuxi Luo   +5 more
wiley   +1 more source