Results 111 to 120 of about 295,841 (379)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Single-chamber Versus Dual-chamber Implantable Cardioverter Defibrillators: Do We Need Physiologic Pacing in The Course? [PDF]

, 2006
Background: Many patients with ICD receive different antiarrhythmic drugs (e.g. sotalol, amiodarone, β-blockers) because of ventricular or atrial tachycardias.
Buck, Thomas, Budeus, Marco, Erbel, Raimund, Sack, Stefan, Wieneke, Heinrich   +4 more
core   +2 more sources

Tactile Augmentation of Material Classification via Imperceptible On‐Skin Triboelectricity Collection

Advanced Science, EarlyView.
Human skin inherently forms a body‐coupled triboelectric circuit that enables the generation of triboelectric charges through contact between the skin surface and various materials. Integrated with an on‐finger, substrate‐free microfiber electrode, the material‐specific and personalized triboelectric signals can be imperceptibly collected for machine ...
Junting Huang, Stanley Gong Sheng Ka, Haydn Cheong, Yaru Zhang, Daping Chu, Sohini Kar‐Narayan, Wenyu Wang, Yan Yan Shery Huang   +7 more
wiley   +1 more source

Box Isolation of fibrotic areas: A substrate modification approach in atrial fibrillation patients

Revista Portuguesa de Cardiologia, 2017
In the last years, atrial fibrosis was shown to be an independent predictor of procedural failure in patients with paroxysmal and persistent atrial fibrillation.
Fabian Moser, Doreen Schreiber, Andreas Rieger, Monica Trofin, Christian Pönisch, Hans Kottkamp   +5 more
doaj  

The Automatic External Cardioverter-Defibrillator [PDF]

, 2004
In-hospital cardiac arrest remains a major problem but new technologies allowing fully automatic external defibrillation are available. These technologies allow the concept of “external therapeutic monitoring” of lethal arrhythmias.
Barón-Esquivias, Gonzalo, Martínez-Rubio, Antoni   +1 more
core   +2 more sources

Resolving Artifacts in Voltage‐Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings

Advanced Science, EarlyView.
Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei, Alexander P. Clark, Michael Clerx, Siyu Wei, Meye Bloothooft, Teun P. de Boer, David J. Christini, Trine Krogh‐Madsen, Gary R. Mirams   +8 more
wiley   +1 more source

Delta-wave automatic mapping of the manifest accessory pathway

Frontiers in Cardiovascular Medicine
BackgroundDespite the high success rate of radiofrequency catheter ablation (RFCA) in Wolff-Parkinson-White Syndrome (WPW), localizing the successful ablation site can be challenging and may require multiple radiofrequency (RF) applications.ObjectiveThis
Saverio Iacopino, Gennaro Fabiano, Paolo Sorrenti, Andrea Petretta, Jacopo Colella, Alessandro Di Vilio, Giovanni Statuto, Nicolangelo Diomede, Paolo Artale, Pasquale Filannino, Pasquale Filannino, Antonino Pardeo, Filippo Placentino, Giuseppe Campagna, Gianluca Peluso, Edoardo Cecchini, Federico Cecchini, Giuseppe Speziale, Giuseppe Speziale, Fiorenzo Gaita   +19 more
doaj   +1 more source

Osborn Waves: History and Significance [PDF]

, 2004
The Osborn wave is a deflection with a dome or hump configuration occurring at the R-ST junction (J point) on the ECG (Fig. 1). In the historical view, different names have been used for this wave in the medical literature, such as “camel-hump sign ...
Atarashi, Hirotsugu, Hirayama, Yoshiyuki, Katoh, Takao, Kobayashi, Yoshinori, Kodani, Eitaroh, Maruyama, Mitsunori, Takano, Teruo   +6 more
core   +2 more sources

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Arrhythmic Risk Stratification in Patients with Arrhythmogenic Cardiomyopathy

Diagnostics
Arrhythmogenic cardiomyopathy is a heart disease in which the heart muscle is replaced by scar tissue. This is the main substrate for the development of malignant ventricular arrhythmias.
Marisa Varrenti, Eleonora Bonvicini, Leandro Fabrizio Milillo, Ilaria Garofani, Marco Carbonaro, Matteo Baroni, Lorenzo Gigli, Giulia Colombo, Federica Giordano, Raffaele Falco, Antonio Frontera, Roberto Menè, Alberto Preda, Sara Vargiu, Patrizio Mazzone, Fabrizio Guarracini   +15 more
doaj   +1 more source