Results 121 to 130 of about 188,005 (360)

Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex

Glia, Volume 71, Issue 2, Page 187-204, February 2023., 2023
Main Point Loss of oligodendrocyte ErbB receptor signaling leads to A1 hypomyelination, reduced PV expression and density of PV+ neurons and synapses, hypoconnectivity of inhibitory circuits and shift of the E/I balance towards excitation. Abstract For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination
Beatriz C. Borges, Xiangying Meng, Patrick Long, Patrick O. Kanold, Gabriel Corfas   +4 more
wiley   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning

Glia, Volume 71, Issue 2, Page 415-430, February 2023., 2023
Main Points A subset of OPCs do not express Olig2, of which population peaks in the juvenile brain while wanes with age. Plastic changes of the brain by acute injuries or complex motor learning stop the expression of Olig2 in OPCs. Abstract Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain; however, their function ...
Li‐Pao Fang, Qing Liu, Erika Meyer, Anna Welle, Wenhui Huang, Anja Scheller, Frank Kirchhoff, Xianshu Bai   +7 more
wiley   +1 more source

Multi‐Shank 1024 Channels Active SiNAPS Probe for Large Multi‐Regional Topographical Electrophysiological Mapping of Neural Dynamics

Advanced Science, EarlyView.
This research article introduces a novel CMOS neural probe with 1024 channels distributed across eight shanks. The SiNAPS probe allows for the simultaneous recording of both local field potentials and action potentials in large brain areas. The probe's design allows for detailed mapping and linking neural dynamics and population unit activity, as ...
Gian Nicola Angotzi, Mihály Vöröslakos, Nikolas Perentos, Joao Filipe Ribeiro, Matteo Vincenzi, Fabio Boi, Aziliz Lecomte, Gabor Orban, Andreas Genewsky, Gerrit Schwesig, Deren Aykan, György Buzsáki, Anton Sirota, Luca Berdondini   +13 more
wiley   +1 more source

Double gene mutations of LRSAM1 and REEP1 and a new REEP1 mutation site found in a patient with amyotrophic lateral sclerosis with subjective paresthesia: A case report

Ibrain, EarlyView., 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. Leucine‐rich repeats and sterility α mutations in motif 1 (LRSAM1) has been proven to be involved in the pathogenesis of ALS.
Ji‐Yao Qin, Zun‐Lin Zhou, Yuan‐Qing Zhou, Ya Chen, Xiao‐Yan Yang, Hai‐Qing Zhang, Zu‐Cai Xu   +6 more
wiley   +1 more source

An active inference strategy for prompting reliable responses from large language models in medical practice

npj Digital Medicine
Continuing advances in Large Language Models (LLMs) are transforming medical knowledge access across education, training, and treatment. Early literature cautions their non-determinism, potential for harmful responses, and lack of quality control.
Roma Shusterman, Allison C. Waters, Shannon O’Neill, Marshall Bangs, Phan Luu, Don M. Tucker   +5 more
doaj   +1 more source

Advanced management of ventricular arrhythmias in chronic Chagas cardiomyopathy

Heart Rhythm O2, 2021
Chagas cardiomyopathy is a parasitic infection caused by Trypanosoma cruzi. Structural and functional abnormalities are the result of direct myocardial damage by the parasite, immunological reactions, dysautonomia, and microvascular alterations.
David Santacruz, MD, Fernando Rosas, MD, Carina Abigail Hardy, MD, Diego Ospina, MD, Andrea Nathalie Rosas, MD, Juan Manuel Camargo, MD, Juan José Bermúdez, MD, Juan Felipe Betancourt, MD, Víctor Manuel Velasco, MD, Mario D. González, MD, FHRS   +9 more
doaj  

THE ELECTROPHYSIOLOGY AND PHARMACOLOGY OF LOBSTER NEUROMUSCULAR SYNAPSES [PDF]

, 1959
Harry Grundfest, J. P. Reuben, W. H. Rickles   +2 more
openalex   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Major incidental findings on routine cardiovascular magnetic resonance imaging prior to first-time catheter ablation of atrial fibrillation

International Journal of Cardiology: Heart & Vasculature, 2022
Introduction: Preprocedural cardiovascular magnetic resonance (CMR) or computed tomography (CT) imaging of the left atrium/pulmonary veins is usually employed to guide catheter ablation of atrial fibrillation (AFCA).
Micaela Ebert, Rebekka Karrengarn, Cosima Jahnke, Simon Kircher, Sabrina Oebel, Michael Döring, Gerhard Hindricks, Ingo Paetsch, Sergio Richter   +8 more
doaj