Results 61 to 70 of about 243,630 (401)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Atrial fibrillation: A review of modifiable risk factors and preventive strategies

Romanian Journal of Internal Medicine, 2019
Atrial fibrillation (AF), as the most common cardiac arrhythmia worldwide, is associated with increased mortality and morbidity. Successful therapeutic strategies have been introduced so far, but they are associated with significant costs.
Shamloo Alireza Sepehri, Dagres Nikolaos, Arya Arash, Hindricks Gerhard   +3 more
doaj   +1 more source

Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements

Frontiers in Signal Processing, 2023
The combination of electrophysiology and electrochemistry acquisition methods using a single carbon fiber microelectrode (CFM) in the brain has enabled more extensive analysis of neurochemical release, neural activity, and animal behavior. Predominantly,
Ashwin K. Avula, Abhinav Goyal, Abhinav Goyal, Abhinav Goyal, Aaron E. Rusheen, Aaron E. Rusheen, Aaron E. Rusheen, Jason Yuen, Jason Yuen, Warren O. Dennis, Diane R. Eaker, Joshua B. Boesche, Charles D. Blaha, Charles D. Blaha, Kevin E. Bennet, Kevin E. Bennet, Kevin E. Bennet, Kendall H. Lee, Kendall H. Lee, Kendall H. Lee, Hojin Shin, Hojin Shin, Hojin Shin, Yoonbae Oh, Yoonbae Oh, Yoonbae Oh   +25 more
doaj   +1 more source

Challenges and opportunities for large-scale electrophysiology with Neuropixels probes

Current Opinion in Neurobiology, 2018
Electrophysiological methods are the gold standard in neuroscience because they reveal the activity of individual neurons at high temporal resolution and in arbitrary brain locations. Microelectrode arrays based on complementary metal-oxide semiconductor
Nicholas A. Steinmetz, C. Koch, K. Harris, M. Carandini   +3 more
semanticscholar   +1 more source

Self‐Healing and Stretchable Synaptic Transistor

Advanced Functional Materials, EarlyView.
A self‐healing stretchable synaptic transistor (3S‐T) is realized using a p‐PVDF‐HFP‐DBP/PDMS‐MPU‐IU bilayer as gate insulator, where dipole‐dipole interaction enhances polarization to achieve a large memory window. Leveraging its neuronal biomimicry, the synaptic transistor demonstrates electrically compatibility with the biological brain. Furthermore,
Hyongsuk Choo, Sangyong Park, Yoonyi Jeong, Jaepyo Jang, Duhwan Seong, In Soo Kim, Myung‐Gil Kim, Mikyung Shin, Minah Suh, Donghee Son, Jin‐Hong Park   +10 more
wiley   +1 more source

Calibration of ionic and cellular cardiac electrophysiology models

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2020
Cardiac electrophysiology models are among the most mature and well‐studied mathematical models of biological systems. This maturity is bringing new challenges as models are being used increasingly to make quantitative rather than qualitative predictions.
Dominic G. Whittaker, M. Clerx, Chon Lok Lei, D. Christini, Gary R. Mirams   +4 more
semanticscholar   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

How does the programmed atrial sensitivity related to undersensing of atrial fibrillation and optimal automatic mode switching?

, 1998
19th Annual Scientific Sessions of North American Society of Pacing and Electrophysiology, San Diego, CA, USA, 6-9 May 1998. In Pacing and Clinical Electrophysiology, 1998, v. 21 n. 4, pt. 2, p.
Chung, F, Leung, SK, Tse, HF, Lau, CP, Tang, MO, Ayers, GM, Lam, C   +6 more
core   +2 more sources

An adaptive, preconditioned, electromechanical model for the simulation of cardiac arrhythmias [PDF]

, 2012
In this thesis a coupled model of cardiac electromechanical activity is presented, using the finite element method to model both electrophysiology and mechanics within a deforming domain.
Kirk, Nathan Robert
core