Results 61 to 70 of about 198,491 (299)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

How does the programmed atrial sensitivity related to undersensing of atrial fibrillation and optimal automatic mode switching?

, 1998
19th Annual Scientific Sessions of North American Society of Pacing and Electrophysiology, San Diego, CA, USA, 6-9 May 1998. In Pacing and Clinical Electrophysiology, 1998, v. 21 n. 4, pt. 2, p.
Chung, F, Leung, SK, Tse, HF, Lau, CP, Tang, MO, Ayers, GM, Lam, C   +6 more
core   +2 more sources

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Diastolic mitral regurgitation after dual chamber pacemaker

Indian Pacing and Electrophysiology Journal
First-degree Atrioventricular (AV) block can lead to symptoms of heart failure, due to AV dyssynchrony. We report a case of 40-year-old male with symptomatic 2:1 AV block with intermittent first-degree AV block who was implanted with dual chamber ...
Harshal Pamecha, Sridevi Chennapragada, David Sampath Kumar Gollapally, Calambur Narasimhan   +3 more
doaj   +1 more source

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]

, 2012
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Felix Schmidt, Armin Giese, Hans Kretzschmar, Levin, Johannes, Kamp, Frits, Kretzschmar, Hans, Bötzel, Kai, Kai Bötzel, Johannes Levin, Schmidt, Felix, Frits Kamp, Giese, Armin   +11 more
core   +2 more sources

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Repeat ablation for paroxysmal atrial fibrillation – Does adenosine play a role in predicting pulmonary vein reconnection patterns?

Indian Pacing and Electrophysiology Journal, 2018
Background: Pulmonary vein (PV) reconduction after PV isolation (PVI) unmasked by adenosine is associated with a higher risk for paroxysmal atrial fibrillation (PAF) recurrence.
M. Kottmaier, F. Bourier, S. Wünscher, M. Kornmayer, V. Semmler, S. Lengauer, M. Telishevska, K. Koch-Büttner, E. Risse, S. Brooks, G. Hessling, I. Deisenhofer, T. Reents   +12 more
doaj   +1 more source

A Confused Pacemaker [PDF]

, 2016
The electrocardiogram (ECG) raises the question of inappropriate device behavior and the possibility of ventricular lead oversensing causing failure of ventricular pacing.
Refaat, Marwan M., Khoury, Maurice Y., Abi-Saleh, Bernard S., ElBaba, Mohammad   +3 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source