Results 131 to 138 of about 68,565 (138)
Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection
Cell Proliferation, Volume 58, Issue 4, April 2025.Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti‐apoptotic proteins.
Yu Chen +8 more
wiley +1 more source
Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
Cell Proliferation, Volume 58, Issue 4, April 2025.This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
wiley +1 more source
A deterministic model of the effect of electric field on chemotherapeutics delivery into a tumor [PDF]
, 2017 Achenie, Luke, Moarefian, Maryam
core +1 more source
Cell Proliferation, EarlyView.Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang +23 more
wiley +1 more source
Rare dysfunctional SCN2A variants are associated with malformation of cortical development
Epilepsia, Volume 66, Issue 3, Page 914-928, March 2025.Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic variants in SCN2A are associated with a spectrum of neurodevelopmental disorders.
Jérôme Clatot +19 more
wiley +1 more source
The FEBS Journal, EarlyView.Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés +19 more
wiley +1 more source
Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application
The FEBS Journal, EarlyView.Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie +3 more
wiley +1 more source
DmdA‐independent lag phase shortening in Phaeobacter inhibens bacteria under stress conditions
The FEBS Journal, EarlyView.The lag phase is crucial for resuming bacterial growth and can be shortened by fueling the methionine cycle with methyl groups from DMSP or other methylated compounds. While DmdA is the primary DMSP demethylase in Phaeobacter inhibens, stress activates additional enzymes like Bmt. This enzymatic flexibility allows bacteria to exit the lag phase rapidly,
Delia A. Narváez‐Barragán +2 more
wiley +1 more source