Results 211 to 220 of about 22,824 (329)

Rats in Epilepsy Research: A Bibliometric Analysis of Citations Between 1969 and 2020 on Experimental Models in Epilepsy. [PDF]

open access: yesCureus, 2023
Rubio C   +6 more
europepmc   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

open access: yesEpilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson   +9 more
wiley   +1 more source

Investigation of Anticonvulsant Potential of <i>Morus alba</i>, <i>Angelica archangelica</i>, <i>Valeriana officinalis</i>, and <i>Passiflora incarnata</i> Extracts: In Vivo and In Silico Studies. [PDF]

open access: yesInt J Mol Sci
Suciu F   +13 more
europepmc   +1 more source

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

open access: yesEpilepsia, EarlyView.
Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott   +2 more
wiley   +1 more source

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed   +8 more
wiley   +1 more source

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