Results 171 to 180 of about 9,796 (284)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster. [PDF]

Sci Rep
Corke J, Huertas-Radi M, Landgraf M, Baines RA.   +3 more
europepmc   +1 more source

Nursing Students' Experiences of How a Sudden Change in the Work Environment due to the COVID‐19 Pandemic Influences the Clinical Learning Environment: A Qualitative Study

Journal of Advanced Nursing, Volume 82, Issue 5, Page 5218-5228, May 2026.
ABSTRACT Aim To explore nursing students' experience of how the COVID‐19 pandemic influenced the learning environment in clinical setting and how they responded to the change. Design Qualitative descriptive interview study. Methods Eleven third‐year baccalaureate nursing students from a University College in Northern Denmark participated in individual ...
Tanja Thomassen, Siri Lygum Voldbjerg
wiley   +1 more source

Enantioselective comparative analysis of the anticonvulsant potency of fenfluramine and norfenfluramine in mice. [PDF]

Epilepsia
Sheeni Y, Erenburg N, Barasch D, Shekh-Ahmad T, Perucca E, Bialer M.   +5 more
europepmc   +1 more source

International Competencies of Advanced Practice Nurses in Critical Care: An Integrative Review

Journal of Advanced Nursing, Volume 82, Issue 5, Page 4766-4785, May 2026.
ABSTRACT Aim This review explores the roles, competencies, and scope of practice of APNs in critical care based on international literature. It also derives implications for the development of advanced nursing roles in Austria. Design Integrative review.
Verena‐Katrin Buchner, Kathrin Pann, Roland Essl‐Maurer, Manela Glarcher, Andre Ewers   +4 more
wiley   +1 more source

"Adverse event reports of seizure for insomnia medication from 1967 to 2023". The challenge of using hypnotic medication in people with epilepsy. [PDF]

Front Neurol
Di Mauro G, Liguori C.
europepmc   +1 more source

Challenges in the End‐of‐Life Care for Patients With Severe Persistent Mental Illness: A Case Series

Psychogeriatrics, Volume 26, Issue 3, May 2026.
ABSTRACT Introduction Despite reduced life expectancy and high rates of comorbidity, individuals with severe persistent mental illness (SPMI) face significant disparities in healthcare access and quality, which extends to palliative and end‐of‐life (EOL) care.
Kaushadh Jayakody, Isha Bajaj, Doug Blomeley   +2 more
wiley   +1 more source

Experimental models of epilepsy: A comprehensive review of mechanisms, translational relevance, and future directions. [PDF]

Vet World
Jiji PJ, Rai R, Kumar NA, Blossom V, Pai MM, Rai AR, Vadgaonkar R, Nayak SD.   +7 more
europepmc   +1 more source

Validation of the German Version of the Movement Disorder Society Non‐Motor Scale (MDS‐NMS)

Movement Disorders Clinical Practice, Volume 13, Issue 5, Page 1346-1348, May 2026.
Jonas Bendig, Anika Frank, Adrianna Lipska‐Dieck, Kristof Wunderlich, David Geißler‐Lösch, Isabel Wurster, Roswitha Kemmner, Kathrin Brockmann, Sheng Luo, Christopher G. Goetz, Glenn T. Stebbins, Pablo Martinez‐Martin, Tiago A. Mestre, Alvaro Sanchez‐Ferro, Monica M. Kurtis, Michelle H.S. Tosin, Roberta Balestrino, Chi‐Ying R. Lin, Carmen Gasca‐Salas, Heinz Reichmann, Bjoern H. Falkenburger   +20 more
wiley   +1 more source