Results 141 to 150 of about 230,711 (334)

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advanced Science, EarlyView.
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang, Fuwei Li, Lin Lv, Zhenfan Wen, Zhongren Xu, Yixia Yang, Chunyang Bi, Wukun Liu   +10 more
wiley   +1 more source

Poly(ethyleneglycol) in electrospray ionization (ESI) mass spectrometry [PDF]

, 2000
S. Varray, J.‐L. Aubagnac, Frédéric Lamaty, René Lazaro, Jean Martínez, Christine Enjalbal   +5 more
openalex   +1 more source

MEMS Mass Spectrometers: the Next Wave of Miniaturization [PDF]

, 2015
Syms, R, Wright, S
core   +1 more source

Honeysuckle‐Derived Nanovesicles Regulate Gut Microbiota for the Treatment of Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study explores honeysuckle‐derived nanovesicles (HNVs) for treating inflammatory bowel disease. Orally administered HNVs alleviates colitis in mice by repairing the gut barrier, reducing inflammation, and restoring a healthy gut microbiota.
Yuanyuan Wang, Yuanhao Zhou, Qingyuan Wu, Yishu Li, Yilin Huang, Kexin Yu, Ping Li, Zhenye Lv, Haotian Liu, Hai Zou, Huiyu Liu, Xiaozhou Mou   +11 more
wiley   +1 more source

Studies on metal-ion complex formation of crown ether derivatives incorporating a photoionizable spirobenzopyran moiety by electrospray ionization mass spectrometry [PDF]

, 2000
Keiichi Kimura, Hidefumi Sakamoto, Shinpei Kado, Ryuichi Arakawa, Masaaki Yokoyama   +4 more
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Solvent Effects on the Conformation of the Transmembrane Peptide Gramicidin A: Insights from Electrospray Ionization Mass Spectrometry [PDF]

, 2000
Mario Bouchard, Dennis R. Benjamin, Paula Tito, Carol V. Robinson, Christopher M. Dobson   +4 more
openalex   +1 more source

Mass spectrometric and quantum chemical studies of gold speciation in water vapor [PDF]

, 2014
The mobility and transport of gold in hydrothermal vapors is strongly influenced by the molecular speciation of gold, which is highly sensitive to pH, oxidation state and water vapor pressure. In this study, electrospray ionization mass spectrometry (ESI-
Lemke, KH
core  

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

Method validation of clonidine hydrochloride in human plasma by LC-MS technique

Pharmaceutical and Biomedical Research, 2015
A simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma.
Hossein Danafar
doaj