Results 241 to 250 of about 142,148 (337)

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

ChemBioChem, EarlyView.
This study reports the synthesis of five tetrazine‐coordinated, half‐sandwich iridium complexes and extensively describe their reactivity. Live cell fluorescent bioorthogonal labeling reveals the nuclear tropism of the most cytotoxic complex. Intracellular imaging of anticancer metallodrugs often relies on prelabeling with organic fluorophores, which ...
Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot, Michèle Salmain   +6 more
wiley   +1 more source

Improved ion detection sensitivity in mass spectrometry imaging using tapping-mode scanning probe electrospray ionization to visualize localized lipids in mouse testes. [PDF]

Anal Bioanal Chem
Otsuka Y, Okada M, Hashidate-Yoshida T, Nagata K, Yamada M, Goto M, Sun M, Shindou H, Toyoda M.   +8 more
europepmc   +1 more source

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

ChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl, Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Mauricio Testanera, Kilian Rauscher, Matthias Lenz, Arne Skerra   +7 more
wiley   +1 more source

Modern Electrospray Ionization Mass Spectrometry Techniques for the Characterization of Supramolecules and Coordination Compounds. [PDF]

Anal Chem
Geue N.
europepmc   +1 more source

Boron‐Based Functionalities Enhance the Potency of 2,5‐Dimethylfuran‐Based IDO1 Inhibitors

ChemBioChem, EarlyView.
Indoleamine‐2,3‐dioxygenase‐1 (IDO1), a key immunoregulatory enzyme, is inhibited by novel boron derivatives (closo‐1,2‐ and 1,7‐carborane, boronic acids and esters, and benzoxaboroles) of 2,5‐dimethylfuran, each displaying low μM affinity for the human recombinant enzyme.
Thomas J. C. Carraro, Samrat Dasgupta, Jacqueline Ku, Shane R. Thomas, Louis M. Rendina   +4 more
wiley   +1 more source

Tumor-Promoted Changes in Pediatric Brain Histology Can Be Distinguished from Normal Parenchyma by Desorption Electrospray Ionization Mass Spectrometry Imaging. [PDF]

Biomedicines
Seidinger AL, Silva FLT, Euzébio MF, Krieger AC, Meidanis J, Gutierrez JM, Bezerra TMS, Queiroz L, Silva AAR, Hoffmann IL, Daiggi CMM, Tedeschi H, Eberlin MN, Eberlin LS, Yunes JA, Porcari AM, Cardinalli IA.   +16 more
europepmc   +1 more source

Simultaneous determination of enantiomers of structurally related anticholinergic analogs in human serum by liquid chromatography–electrospray ionization mass spectrometry with on-line sample cleanup

, 2001
Vladimı́r Čápka, Yan Xu
openalex   +2 more sources

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

ChemBioChem, EarlyView.
Herein, DC peptides consisting of the cell‐penetrating peptide sC18* and a Asp–His–His–Cys (DHHC) motif derived from human ZDHHC palmitoyltransferase are highlighted. DC peptides demonstrate high cellular internalization into various cellular models, exert cytotoxic effects against cancerous cells, and alter the function and localization of known ...
Katharina Stillger, Eric Platz‐Baudin, Florian Friedland, Melina Ruppel, Coco‐Louisa Sticker, Anne Bodenhausen, Erik Noetzel, Ines Neundorf   +7 more
wiley   +1 more source

Evaluation of high temperature glycation of proteins and peptides by electrospray ionization mass spectrometry.

, 2001
Piotr Stefanowicz, Janusz Boratyński, Urszula Kańska, Inga Petry, Zbigniew Szewczuk   +4 more
openalex   +2 more sources

Purple and red rice (Oryza sativa L.) bran polyphenols show antiobesity and antidiabetic activities

Cereal Chemistry, EarlyView.
Abstract Background and Objectives Rice bran is a source of bioactive polyphenols. This study aimed to characterize the antidiabetic potential of different rice brans (one brown, two red, and two purple) by examining their ability to inhibit α‐amylase, α‐glucosidase, and pancreatic lipase, and to stimulate glucose uptake in adipocytes.
Stephen M. Boue, William Broussard, Abigail Michelz   +2 more
wiley   +1 more source