Results 261 to 270 of about 706,792 (383)

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

New Approach Combining Molecular Fingerprints and Machine Learning to Estimate Relative Ionization Efficiency in Electrospray Ionization

ACS Omega, 2020
Alfred W. Mayhew, David O. Topping, Jacqueline F. Hamilton   +2 more
doaj   +1 more source

Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry-Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Basuri P, Safferthal M, Kovacevic B, Schorr P, Riedel J, Pagel K, Volmer DA.   +6 more
europepmc   +1 more source

Identification of the acid-induced degradation products of omeprazole and 5-hydroxyomeprazole by high resolution mass spectrometry [PDF]

, 2018
Aherne, Bahlmann, Boxall, Brenton, Bruni, Brändström, Brändström, Brändström, Cao, Halling-Sørensen, Heberer, Holčapek, Jones, Karni, Kind, Kümmerer, Lagerstrom, Lindberg, Lindberg, López-Serna, Makarov, Makarov, McLafferty, Olbe, Patiny, Schäfer, Stumpf, Watson, Weidolf   +28 more
core   +1 more source

Electrospray ionization mass spectrometry for the analysis of proteins and small molecules

, 2000
Gregg A. Pratt
openalex   +2 more sources

Accurate Quantification of Multifunctional C_2-3 Organosulfates in Atmospheric Aerosols Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry: Overcoming Matrix Effects and Underestimation. [PDF]

Environ Sci Technol
Liang S, Wang Y, Chen H, Chan W, Yu JZ.
europepmc   +1 more source

Structural comparison of recombinant human macrophage colony stimulating factor β and a partially reduced derivative using hydrogen deuterium exchange and electrospray ionization mass spectrometry [PDF]

, 2001
Y. Heidi Zhang, Xuguang Yan, Claudia S. Maier, Michael I. Schimerlik, Max L. Deinzer   +4 more
openalex   +1 more source

Rapid Exploration of Chemical Space by High-Throughput Desorption Electrospray Ionization Mass Spectrometry. [PDF]

J Am Chem Soc
Huang KH, Morato NM, Feng Y, Toney A, Cooks RG.   +4 more
europepmc   +1 more source

Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis

Proceedings of the National Academy of Sciences of the United States of America, 2014
David Calligaris, Diana L. Caragacianu, Xiaohui Liu, I. Norton, C. Thompson, A. Richardson, M. Golshan, M. Easterling, S. Santagata, D. Dillon, F. Jolesz, N. Agar   +11 more
semanticscholar   +1 more source

Determination of Cabergoline by Electrospray Ionization Tandem Mass Spectrometry: Picogram Detection via Column Focusing Sample Introduction

, 2001
Bruce A. Kimball, Thomas J. DeLiberto, John J. Johnston   +2 more
openalex   +2 more sources