Results 271 to 280 of about 230,711 (334)

Modeling the relative response factor of small molecules in positive electrospray ionization. [PDF]

open access: yesRSC Adv
Abrahamsson D   +5 more
europepmc   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

open access: yesAngewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann   +10 more
wiley   +1 more source

Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization

open access: yesAngewandte Chemie International Edition, EarlyView.
Illuminating the Oxytocin Receptor: Here we present the development of fluorescent peptide tracers for the simultaneous visualization and activation of the oxytocin receptor, an important G protein‐coupled receptor involved in health and disease. These tracers are powerful new tools to support various imaging and functional studies across biological ...
Monika Perisic Böhm   +11 more
wiley   +1 more source

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