Results 301 to 310 of about 718,278 (381)

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

[Determination of genotoxic impurity in the bulk drug of crizotinib by high performance liquid chromatography-electrospray ionization tandem mass spectrometry]. [PDF]

Se Pu
Zhan XB, Qin Y, Yan Y, Zhou J, Zhao LS.
europepmc   +1 more source

Untargeted Metabolomics Reveals Seasonal and Tissue‐Specific Metabolic Shifts in Holothuria cinerascens

Chemistry &Biodiversity, EarlyView.
Untargeted metabolic profiling of three body tissues from Holothuria cinerascens in South Africa using 1H‐NMR and UPLC–QTOF–MS revealed distinct tissue‐specific and seasonal metabolic variations, with the body wall and gut/mesentery exhibiting high metabolite diversity.
Cassandra Upton, Gerhard Prinsloo, Paul Steenkamp, Moses Okpeku   +3 more
wiley   +1 more source

UHPLC-QTOFMS Urine Drug Screening With Dilute-and-Shoot Sample Preparation and Vacuum-Insulated Probe-Heated Electrospray Ionization. [PDF]

Drug Test Anal
Sundström M, Kriikku P, Ojanperä I, Baessmann C, Pelander A.   +4 more
europepmc   +1 more source

Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties

Chemistry &Biodiversity, EarlyView.
ABSTRACT Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from Synechococcus sp. CACIAM 05 showed cytotoxicity against hCMEC/D3 and MG‐63 cells.
Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Mariana Reis, Rhuana V. Médice, Janaína Morone, Raquel Silva, João Morais, Vitor Vasconcelos, Agenor Valadares Santos   +8 more
wiley   +1 more source

Deep learning prediction of electrospray ionization tandem mass spectra of chemically derived molecules. [PDF]

Nat Commun
Chen B, Li H, Huang R, Tang Y, Li F.
europepmc   +1 more source

Green‐Synthesised Nanoconjugates: Advancing Targeted Photodynamic Therapy for Lung Cancer

Chemistry &Biodiversity, EarlyView.
ABSTRACT Lung cancer is a type of cancer that develops around the airways or lungs and continues to be the leading cause of cancer‐related deaths worldwide. This has necessitated the need for innovative therapeutic strategies to overcome the limits of existing therapies such as surgery, chemotherapy and radiotherapy.
Njabulo Henry Sibanda, Anine Crous, Blassan P. George   +2 more
wiley   +1 more source

Size-Exclusion Chromatography-Electrospray-Ionization Mass Spectrometry To Characterize End Group and Chemical Distribution of Poly(lactide-<i>co</i>-glycolide) Copolymers. [PDF]

J Am Soc Mass Spectrom
Serizawa M, van Delft P, Schoenmakers PJ, Peters RAH, Gargano AFG.   +4 more
europepmc   +1 more source

Antioxidant Activity and Potential Cholesterol Modulating Effect of Punica granatum L. Peel Hydroethanolic Extract

Chemistry &Biodiversity, EarlyView.
Punica granatum peel extract is rich in phenolic compounds, exhibits strong antioxidant activity, and modulates the expression of PCSK9 and LDL receptors. Collectively, these findings suggest a potential cardioprotective effect of the extract. ABSTRACT Lipoprotein metabolism is regulated by several key proteins, notably proprotein convertase subtilisin/
Raja Chaaba, Amel Nakbi, Ilaria Rossi, Hanen Jrah, Zahra Amri, Nicola Ferri, Sonia Hammami, Stefano Dall'Acqua, Mohamed Hammami, Sounira Mehri   +9 more
wiley   +1 more source

Remote Deep-Ultraviolet Laser Ablation in Connection with Electrospray Ionization-Atmospheric Pressure Chemical Ionization (rDUVLAESCI): A Novel Dual Ionization Source for Molecular Mass Spectrometry. [PDF]

Anal Chem
Papoušková B, Fryčák P, Gregar F, Lemr K, Pluháček T.   +4 more
europepmc   +1 more source