Results 281 to 290 of about 776,948 (400)

Spectroscopic and Theoretical Investigation of Water Binding in a Copper-Calcium Complex. [PDF]

J Phys Chem A
de Kler N, Pereverzev AY, Roithová J.
europepmc   +1 more source

Fragmentation pathways of [Re2(μ-OR)3(CO)6]− (R = H, Me) and ligand exchange reactions with oxygen donor ligands, investigated by electrospray mass spectrometry †

, 2000
Chenghua Jiang, T. S. Andy Hor, Yaw Kai Yan, William Henderson, Louise J. McCaffrey   +4 more
openalex   +2 more sources

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Direct Probe Ionisation Mass Spectrometry for Rapid and Accurate Determination of Perfluoroalkyl and Polyfluoroalkyl Substance Concentrations. [PDF]

Rapid Commun Mass Spectrom
Sidnell TP, Mathias SC, Megson DP, Sears PJ, Bussemaker MJ.   +4 more
europepmc   +1 more source

Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea

British Journal of Clinical Pharmacology, EarlyView.
Aims Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.
Natália Bordin Andriguetti, Daniel Thomas Barratt, Joseph Tucci, Paul Pumuye, Andrew Alexander Somogyi   +4 more
wiley   +1 more source

Antibody-Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Fiala J, Schuster D, Heck AJR.
europepmc   +1 more source

The Effect of α‐Mangostin on the Pharmacokinetic Profile of Tofacitinib in Rats Both In Vitro and In Vivo

Biopharmaceutics &Drug Disposition, EarlyView.
α‐mangostin (α‐MG) significantly affected tofacitinib metabolism by competing for the same site in CYP3A4. Co‐administration of these two medicines poses a potential herb–drug interaction. ABSTRACT This study investigated the effects of α‐mangostin (α‐MG) on the pharmacokinetics of tofacitinib in vitro and in vivo, aiming to recommend its appropriate ...
Jiange Yao, Zebei Lu, Quan Zhou, Abdullah Al Mamun, Yaru Shi, Shuanghu Wang, Ying Yao   +6 more
wiley   +1 more source

Optimisation of Heated Electrospray Ionisation Parameters to Minimise In-Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics. [PDF]

Rapid Commun Mass Spectrom
Glenister MA, Mistarz U, Cook K, Stephenson JL, Dickman MJ.   +4 more
europepmc   +1 more source

Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat

Biopharmaceutics &Drug Disposition, EarlyView.
Coadministration of the xanthine oxidase inhibitor, febuxostat, delayed elimination of methotrexate, at least in part, by noncompetitive inhibition of human organic anion transporter 3‐mediated methotrexate transport at clinical concentrations. The findings of this study provide novel information on drug interactions associated with febuxostat ...
Kenji Ikemura, Sakura Kobayashi, Danni Wang, Masahiro Okuda   +3 more
wiley   +1 more source