Results 71 to 80 of about 213,514 (309)
Theory for measuring electric charge density of a ring from scanning force microscopy
AIP AdvancesWe consider a ring that carries an arbitrary electric charge density in the presence of a scanning force microscopy tip. We propose an algorithm that predicts this charge density from knowledge of the electrostatic ring-tip contribution to the total ...
M. Gordon +3 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Electrostatic Field Classifier for Deficient Data [PDF]
, 2009 This paper investigates the suitability of recently developed models based on the physical field phenomena for classification problems with incomplete datasets.
Gabrys, Bogdan +3 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Modelling dielectric charged drop break up using an energy conservation method
, 2008 In the light of experimental evidence a previously published model to predict the charge and mass redistribution when charged dielectric drops break up has been updated. In particular we have taken the dielectric nature of the liquid, the existence of an
Shrimpton, J.S.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Measurement: Sensors, 2020 Measurement of particle’s charge in the pneumatic conveying systems can be used to monitor the flow behaviour (stable or unstable) in dilute phase pneumatic conveying. The particle’s charge can be measured by inductive electrostatic sensors and converted
Amit Kumar +2 more
doaj +1 more source
Point charges optimally placed to represent the multipole expansion of charge distributions. [PDF]
PLoS ONE, 2013 We propose an approach for approximating electrostatic charge distributions with a small number of point charges to optimally represent the original charge distribution. By construction, the proposed optimal point charge approximation (OPCA) retains many
Ramu Anandakrishnan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source