Results 111 to 120 of about 4,761,213 (285)

An Arbitrary Order Virtual Element Method for Free Torsional Vibrations of Beams

Aerospace
In this study, a novel arbitrary order Virtual Element Method (p-VEM) for free torsional vibration analysis of beams with negligible warping is presented. This method can serve as an equivalent beam model for slender aerospace structural components.
Marco Lo Cascio, Alberto Milazzo
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design, synthesis and simulation of fractional-order element using MOS transistors as distributed resistive capacitive devices

Scientific Reports
The article presents a synthesis method to design electrical circuit elements with fractional-order impedance, referred to as a Fractional-Order Element (FOE) or Fractor, that can be implemented by Metal–Oxide–Semiconductor (MOS) transistors.
David Kubanek, Aleksandr Shadrin, Pavel Seda, Jan Dvorak, Jan Jerabek, Vilem Kledrowetz, Cole Christie, Todd J. Freeborn, Pyotr A. Ushakov   +8 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

New spectral element method for the singular perturbation problem of second order

上海师范大学学报. 自然科学版
As the solution of singular perturbation problem of second order has a boundary layer, it is difficult to obtain ideal approximation results for traditional numerical methods.
LIU Zhipeng, TAO Dongya
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

On orders of elements in quasigroups

, 2004
We study the connection between the existence in a quasigroup of m, n- elements for some natural numbers m, n and properties of this quasigroup. The special attention is given for case of m, n-linear quasigroups and m, n-T-quasigroups.
Şcerbacov, V.A., Shcherbacov, V.A.
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A reduced-order boundary element method for two-dimensional acoustic scattering

Frontiers in Physics
This study presents a novel method for wideband acoustic analysis using the Boundary Element Method (BEM), addressing significant computational challenges. Traditional BEM requires repetitive computations across different frequencies due to the frequency-
Senhao Zhong, Senhao Zhong, Xinbo Jiang, Jing Du, Jie Liu   +4 more
doaj   +1 more source