Results 81 to 90 of about 106,105 (261)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

the Utilizing APOS Theory to Enhance Conceptual Understanding through Interactive E-Modules in Elementary Mathematics Learning

Thinking Skills and Creativity Journal
The low learning outcomes in mathematics at SD Negeri 2 Abianbase are caused by reliance on textbooks and a lack of varied learning media, especially digital media. This leads to students struggling to understand the material and being less motivated to
Ni Luh Made Puspita Sari, Gusti Ngurah Sastra Agustika , Agung Ayu Dewi Sutyaningsih   +2 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Student Teams Achievement Division (STAD) Learning Model Assisted by Whole Number Puzzle Media to Enhance Mathematical Knowledge Competence

Mimbar Ilmu
Mathematics learning in elementary schools is often considered difficult and less engaging, particularly in the topic of whole numbers, which affects students’ knowledge competence.
Luh Ayu Trishna Savitri, Gusti Ngurah Sastra Agustika, Anak Agung Ayu Dewi Sutyaningsih   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

The 5E Learning Cycle Model Assisted by Mind Mapping on the Learning Outcomes of IPAS for Fifth-Grade Students

Mimbar Ilmu
The low learning outcomes of fifth-grade students in the subject of IPAS (Integrated Science and Social Studies) have become a fundamental problem in the learning process. One of the contributing factors is the limited variety of learning models and the
Ketut Risa Intania, I Gede Margunayasa, Ni Putu Kusuma Widiastuti   +2 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Teams Games Tournament Cooperative Learning on Whole Number Topics to Improve Fifth-Grade Students’ Problem-Solving Skills

Indonesian Journal of Instruction
Mathematical problem-solving ability is an essential competence that must be mastered by elementary school students; however, it remains relatively low due to the dominance of conventional, teacher-centered instruction that limits students’ active ...
Ni Komang Saniska Pratiwi, I Gusti Putu Suharta, Dewi Anzelina   +2 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source