Results 81 to 90 of about 3,166,049 (353)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Plasma-like Description for Elementary and Composite Quantum Particles

Entropy, 2022
Schrödinger noticed in 1952 that a scalar complex wave function can be made real by a gauge transformation. The author showed recently that one real function is also enough to describe matter in the Dirac equation in an arbitrary electromagnetic or Yang ...
Andrey Akhmeteli
doaj   +1 more source

CHARGED SHELLS AND ELEMENTARY PARTICLES [PDF]

International Journal of Modern Physics A, 2013
We review the General Relativistic model of a (quasi-)pointlike particle represented by a massive shell of electrically charged matter, which displays an ADM mass M equal to the electric charge |Q| in the small-volume limit. We employ the Israel–Darboux's junction equations to explicitly derive this result, and then study the modifications introduced ...
Roberto Casadio, Roberto Casadio
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Trapped ion emulation of electric dipole moment of neutral relativistic particles

, 2012
The electric dipole moments of various neutral elementary particles, such as neutron, neutrinos, certain hypothetical dark matter particles and others, are predicted to exist by the standard model of high energy physics and various extensions of it ...
A. Messiah, B. Thaller, C. Kittel, Nikolay V. Vitanov, Peter A. Ivanov, Tihomir G. Tenev   +5 more
core   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Direct and Indirect Probes for Composite Dark Matter

Frontiers in Physics, 2019
Dark matter candidates are one of the profound signatures of new physics, reflecting existence of new stable particles. If such particles are charged they can bind with ordinary electrons, forming anomalous isotopes.
Maxim Y. Khlopov, Maxim Y. Khlopov, Maxim Y. Khlopov   +2 more
doaj   +1 more source

Fermion masses in a model for spontaneous parity breaking

, 2001
In this paper we discuss a left-right symmetric model for elementary particles and their connection with the mass spectrum of elementary fermions. The model is based on the group $SU(2)_L\otimes SU(2)_R\otimes U(1)$. New mirror fermions and a minimal set
Coutinho, Y. A., Porto, C. M., Simoes, J. A. Martins   +2 more
core   +1 more source