Results 41 to 50 of about 367,900 (317)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Elementary School, 2020 This research aims to examine the effect of project-based learning through biopore learning models on the learning outcomes of elementary school students in grade V, to examine the effect of project-based learning through biopori learning outcomes on ...
Didi Prabowo +2 more
doaj +1 more source
MEMBENTUK AKHLAK DI ERA REVOLUSI INDUSTRI 4.0 DENGAN PERAN PENDIDIKAN AGAMA ISLAM
Elementary School, 2021 Advances in science and technology entering the millennial era of industrial revolution 4.0 can be enjoyed by mankind. But onthe other hand, the advancement of science and technology also has a negative impact on many people, especially in today's ...
Arip Febrianto, Norma Dewi Shalikhah
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
PENGEMBANGAN BAHAN AJAR MULTIMEDIA UNTUK PEMBELAJARAN IPA SD
Elementary School, 2020 Based on preliminary study, it was found the problem that teachers often had difficulty to give real picture related to materials which are beyond the observation of students. The limitations of media and learning resources forced teachers to deliver the
Dhian Dwi Nur Wenda
doaj +1 more source
Elementary School, 2021 The objectives of this study are : (1) to analyze the real condition of students’achievements in SD Muhammadiyah Wirobrajan II in implementing Iqro method,(2) To analyze the real condition of students’ achievements in SD Muhammadiyah Wirobrajan II in ...
Sri Agustinawati +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source