Results 61 to 70 of about 1,039,373 (358)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Middle and elementary school students’ changes in self-determined motivation in a basketball unit taught using the Tactical Games Model [PDF]

open access: yes, 2017
Studies examining student motivation levels suggest that this is a significant factor in students’ engagement in physical education and may be positively affected when teachers employ alternative pedagogical models such as game-centered approaches (GCAs).
Gil-Arias, Alexander   +3 more
core   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The Complexity of Argumentation Regarding Socioscientific Issue at Elementery, Middle, and High School [PDF]

open access: yes, 2018
The Student's argument can be raised and developed using socioscientific issues. Socio-scientific issues about health is one of the social problems that the subject of public debate.
Amalia, N. F. (Nur)   +3 more
core  

QCD under extreme conditions: an informal discussion

open access: yes, 2013
We present an informal discussion of some aspects of strong interactions under extreme conditions of temperature and density at an elementary level. This summarizes lectures delivered at the 2013 CERN -- Latin-American School of High-Energy Physics and ...
Fraga, E. S.
core   +1 more source

Integrating Item Accuracy and Reaction Time to Improve the Measurement of Inhibitory Control Abilities in Early Childhood [PDF]

open access: yes, 2017
Efforts to improve children’s executive function are often hampered by the lack of measures that are optimized for use during the transition from preschool to elementary school.
Blair, Clancy B.   +3 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Sports effect on depression level of elementary school students

open access: yesTürk Spor ve Egzersiz Dergisi, 2017
The purpose of this study is to analyze sports and exercises effects on depression levels of elementary school students. The research group formed a total of 203 students, including 104 students who exercise (amateur athletes, playing in school teams ...
Ahmet Gursel Oguz, Oksay Oguz
doaj   +1 more source

Human Rights Education at Elementary School Level [PDF]

open access: yes, 2014
Human rights could be commonly defined as the rights which are inherent in our nature and without which we cannot live as human beings. These are the minimal rights that every individual must have by virtue f his being a member of human family.
Satyaprakasha, C.V.
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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