Results 171 to 180 of about 10,500,411 (340)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Understanding the cognitive cost of multimedia learning: effects of visual load and language proficiency. [PDF]

Cogn Res Princ Implic
Bali C, Tasdelen B, Bandi S, Zsidó A.
europepmc   +1 more source

Main Elements of Logistics [PDF]

, 2014
Gubkina, V.V., Tkachenko, Vitaliy, Trybitsin, M.N.   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Independent, ongoing clade-specific expansions of IS5 elements in Pseudomonas syringae. [PDF]

Microb Genom
Baltrus DA, Sweten A, Conomos T, Ponvert N, Woodson JD, Konkel Z, Jacobs J.   +6 more
europepmc   +1 more source

Design of Cooperative Learning Module Elements to Improve Indonesian Vocabulary of Early Childhood [PDF]

Ratin Wahyu Juni Atma, Juppri Bacotang, Mazlina Che Mustafa, M Zainul Hafizi, Lailatul Ismi   +4 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Note on Mr. Pocock's Paper “On a Certain Relation between the Elements of Planets and Satellites.” [PDF]

, 1919
H. H. Turner
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Whole-genome assembly and annotation of the acorn weevil, Curculio nanulus (Coleoptera: Curculionidae). [PDF]

G3 (Bethesda)
Davis DD, Charles MA, McKenna DD, Frandsen PB.   +3 more
europepmc   +1 more source