Results 91 to 100 of about 1,191,943 (292)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

ST Elevation in aVR with Coexistent Multilead ST Depression [PDF]

, 2017
History of present illness: An 80-year-old female with a history of Crohn’s disease presented to the emergency department with chest pain. She had two weeks of exertional chest pain that preceded an episode of chest pain immediately prior to arrival ...
Cooper, Benjamin,, Benjamin Cooper, Cooper, Benjamin   +2 more
core   +1 more source

An inventory of epigeal ants of the western Soutpansberg Mountain Range, South Africa

Koedoe: African Protected Area Conservation and Science, 2015
The distribution, abundance and sensitivity invertebrates to habitat change are largely unknown. Long-term monitoring of ecological gradients with standardised and comparable protocols can form the basis of a better understanding.
Thinandavha C. Munyai, Stefan H. Foord
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

On the uncertainty of stream networks derived from elevation data: the error propagation approach [PDF]

, 2010
DEM error propagation methodology is extended to the derivation of vector-based objects (stream networks) using geostatistical simulations. First, point sampled elevations are used to fit a variogram model.
Heuvelink, G.B.M., van Loon, E.E.; id_orcid, Loon, E.E., van, Hengl, T.   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Methane and nitrous oxide fluxes across an elevation gradient in the tropical Peruvian Andes [PDF]

, 2014
The authors acknowledge the agencies that funded this research; the UK Natural Environment Research Council (NERC; joint grant references NE/H006583, NE/H007849 and NE/H006753) and the Norwegian Agency for Development Cooperation (Norad; via a sub ...
L. P. Huaraca Quispe, Meir, P., Y. A. Teh, Morley, N., E. Baggs, Smith, P., Huaraca Quispe, L. P., Huaraca- Quispe, Lidia P., S. Jones, Huaraca Quispe, L.P., M. Richards, Baggs, E., Teh, Y. A., Diem, T., Meir, Patrick, Teh, Y.A., P. Meir, Jones, S., P. Smith, T. Diem, N. Morley, Richards, M.   +21 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The TanDEM-X Mission Concept [PDF]

, 2006
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) is an innovative radar interferometry mission to generate a global, consistent and highly accurate Digital Elevation Model (DEM) and to provide a configurable SAR interferometry platform for ...
Werner, Marian, I. Hajnsek, Hajnsek, Irena, Zink, Manfred, H. Fiedler, Moreira, Alberto, A. Moreira, M. Zink, Fiedler, Hauke, G. Krieger, M. Werner, Krieger, Gerhard   +11 more
core   +1 more source