Results 101 to 110 of about 1,139,090 (295)

Spawning cohort trade-offs of reproductive time and output in cyprinid fish along an elevation gradient

Understanding environmental requirements for fish reproduction in natural habitats is crucial for population conservation and restoration. However, such information is extremely scarce for the highly threatened schizothoracine fishes that cover large ...
Liu, X, Ding, C, Chen, J, Tao, J, Bond, N, Ding, L, Sun, J   +6 more
core   +1 more source

Digital Elevation Model Database W42 - A scalable System for Spatial Data [PDF]

, 2008
Digital Elevation Models (DEMs) provide elementary information for various application fields. From a global point of view, there are many different sources to furnish height information of the Earth's surface.
Roth, Achim, Marschalk, Ursula, M. Habermeyer, A. Roth, U. Marschalk, Habermeyer, Martin   +5 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Higher host plant specialization of root‐associated endophytes than mycorrhizal fungi along an arctic elevational gradient

Ecology and Evolution, 2020
How community‐level specialization differs among groups of organisms, and changes along environmental gradients, is fundamental to understanding the mechanisms influencing ecological communities.
Nerea Abrego, Tea Huotari, Ayco J. M. Tack, Björn D. Lindahl, Gleb Tikhonov, Panu Somervuo, Niels Martin Schmidt, Otso Ovaskainen, Tomas Roslin   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Nonlinear cross Gramians and gradient systems [PDF]

, 2007
We study the notion of cross Gramians for non-linear gradient systems, using the characterization in terms of prolongation and gradient extension associated to the system.
Jacquelien M. A. Scherpen, Ionescu, T. C.,, Scherpen, J. M. A., Ionescu, T. C., Tudor C. Ionescu, Scherpen, J. M. A.,   +5 more
core   +2 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Carbon and Nitrogen Availability Drives Seasonal Variation in Soil Microbial Communities along an Elevation Gradient

, 2022
Changes in soil abiotic and biotic properties can be powerful drivers of feedback between plants and soil microbial communities. However, the specific mechanisms by which seasonal changes in environmental factors shape soil microbial communities are not ...
Yongmeng Jiang, Xiaoling Xiong, Weisheng Lin, Cui Deng, Xiaojie Li, Maokui Lyu, Yuming Lu, Jinsheng Xie   +7 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source