Results 51 to 60 of about 46,334 (261)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effect of elevation and aspect on carbon stock of bamboo stands (Bambusa nutans subsp. Cupulata) outside the forest area in Eastern Nepal

Trees, Forests and People
Bamboo has emerged as a promising option for climate change mitigation due to its rapid growth, versatility, and renewability. However, in Nepal, there exists a substantial knowledge gap on carbon (C) stock and the influence of aspect and elevation on C ...
Santosh Ayer, Sachin Timilsina, Rajeev Joshi, Prakash Chaudhary, Jeetendra Gautam, Menuka Maharjan, Himlal Baral, Kishor Prasad Bhatta   +7 more
doaj   +1 more source

Alpha and beta diversity of birds along elevational vegetation zones on the southern slope of Altai Mountains: Implication for conservation

Global Ecology and Conservation, 2019
1: Understanding species diversity patterns is important for conservation planning. We studied birds’ alpha and beta diversity along vegetation gradients in three watersheds in the Altai Mountains, a global biodiversity hotspot; and tested whether ...
Na Li, Hongjun Chu, Yingjie Qi, Chunwang Li, Xiaoge Ping, Yuehua Sun, Zhigang Jiang   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Beyond the Comfort Zone: Elevation, Temperature, Fatigue and Pain Perception

Applied Sciences
This study provides a comprehensive evaluation of the effects of environmental stressors and physical exertion on human nociceptive processing across multiple ecologically relevant conditions. Using a repeated-measures design, participants (N = 45) completed up to five controlled laboratory (thermoclimatic chamber) sessions (baseline, simulated ...
Łukasz Kryst, Magdalena Żegleń, Julia Badzińska, Adrianna Dzidek, Weronika Bogusz, Agnieszka Witkowska, Teo Klos   +6 more
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Climate Change Impacts on Rural Poverty in Low-Elevation Coastal Zones [PDF]

Estuarine, Coastal and Shelf Science, 2015
This paper identifies the low-elevation coastal zone populations and developing regions most vulnerable to sea-level rise and other coastal hazards, such as storm surges, coastal erosion, and salt-water intrusion. The focus is on the rural poor in the low-elevation coastal zone, as their economic livelihoods are especially endangered directly by ...
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source