Results 81 to 90 of about 273,405 (289)

Detection, attribution, and sensitivity of trends toward earlier streamflow in the Sierra Nevada [PDF]

open access: yes, 2007
Observed changes in the timing of snowmelt dominated streamflow in the western United States are often linked to anthropogenic or other external causes.
Bonfils, Celine   +4 more
core   +1 more source

Cellular-Automata model for dense-snow avalanches [PDF]

open access: yes, 2007
This paper introduces a three-dimensional model for simulating dense-snow avalanches, based on the numerical method of cellular automata. This method allows one to study the complex behavior of the avalanche by dividing it into small elements, whose ...
Avolio M. V.   +7 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Environmental determinants of bryophyte community change over time

open access: yesEcosphere
Environmental factors mediating community change over time have been well documented for vascular plants, but not for their non‐vascular relatives, bryophytes.
Eric Shershen   +2 more
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

Zones of Parallel Lines of Elevation in the Earth's Crust [PDF]

open access: yesNature, 1874
HE is a bold man who will predicate that no future discovered fact will disturb even the most widely accepted hypothesis. This being so, all hypotheses being in fact tentative only, and valuable in so far as they enable us to classify and deduce laws from such facts as we know, we ought to welcome every generalisation which groups known facts under ...
openaire   +1 more source

Oribatid assemblies of tropical high mountains on some points of the “Gondwana-Bridge” – a case study [PDF]

open access: yes, 2008
This work is the first part of a series of studies, which introduces the methodological possibilities of coenological and zoogeographical indication and – following the climate, vegetation and elevation zones – the pattern-describing analysis of the main
Balogh, P.   +5 more
core  

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

Climate and soil factors co-derive the functional traits variations in naturalized downy thorn apple (Datura innoxia Mill.) along the altitudinal gradient in the semi-arid environment

open access: yesHeliyon
Plant functional traits are consistently linked with certain ecological factors (i.e., abiotic and biotic), determining which components of a plant species pool are assembled into local communities.
Nasrullah Khan   +7 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling   +16 more
wiley   +1 more source

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