Results 121 to 130 of about 212,868 (349)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Grain Marketing Tools: A Survey of Illinois Grain Elevators [PDF]

open access: yes
As with most sectors of the agriculture economy, the U. S. country grain elevator industry has experienced considerable consolidation and concentration.
Spaulding, Aslihan D., Whitacre, Rick C.
core   +1 more source

Novel payload dynamics on space elevator systems [PDF]

open access: yes, 2006
A simple model of a payload ascending or descending a space elevator is developed to explore the underlying dynamics of the problem. It shown that an unconstrained payload at rest on a space elevator at synchronous radius is in an unstable equilibrium ...
Davis, Chris, McInnes, Colin R.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

A passive gust alleviation system for a light aircraft [PDF]

open access: yes
A passive aeromechanical gust alleviation system was examined for application to a Cessna 172. The system employs small auxiliary wings to sense changes in angle of attack and to drive the wing flaps to compensate the resulting incremental lift.
Harlan, R. B., Roesch, P.
core   +1 more source

The Ohio Grain Marketing Legislation of 1982 and 1983 [PDF]

open access: yes, 1983
PDF pages ...
Baldwin, E. Dean   +2 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy