Results 81 to 90 of about 212,868 (349)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
HortScienceTo explore the falling morphology of multiscale fresh tea leaves at different speeds, this study evaluated the multiscale fresh tea leaves (one bud with two leaves, one bud with one leaf, single leaf, and damaged leaf) at different heights (0.7 m, 0.5 m,
Xu Zhang, Xinyu Zhu, Rongyang Wang
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Modern condition monitoring systems of elevator units
Безопасность техногенных и природных систем, 2019 The paper considers the main systems for monitoring elevator equipment condition, their tasks and functionality. The dependence of the degree of elevator load on the number of storeys of the building is considered.
G. Sh. Khazanovich, D. S. Apryshkin
doaj +1 more source
Conditions at the interface between the space elevator tether and its climber
, 2023 Dennis H. Wright +9 more
openalex +1 more source
A tool for measuring elevator cable tension [PDF]
, 1972 Simple tool for measuring relative cable tension is described, which weighs approximately two pounds, and can be produced at one-tenth cost of present ...
Weaver, E. L.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A space necklace about the earth [PDF]
A space elevator is forecasted for the first quarter of the 21st century, that will consist of a cable attached at the earth's equator, suspended in space by an artificial satellite in geosynchronous orbit.
Polyakov, G.
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Numerical studies of tunneling in a nonharmonic time-dependent potential
, 1992 Azbel' has recently carried out a WKB-analysis of the effects of a nonharmonic time-dependent perturbation embedded in an opaque potential barrier. He suggests the existence of three different transmission regimes: direct tunneling, activation assisted ...
A.-P. Jauho +18 more
core +2 more sources