Results 91 to 100 of about 201,568 (300)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 1999 Excerpt: A behavioral approach used in elimination of unwanted fears or phobias. In flooding the client either is directly exposed to or imagines highly frightening events in a protected setting.
Bufford, Rodger K.
core
Need a Lift? An Elevator Queueing Problem [PDF]
, 2003 Various aspects of the behavior and dispatching of elevators (lifts) were studied. Monte Carlo simulation was used to study the statistics of the several models for the peak demand at uppeak times.
Braun, Richard +7 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
STUDIES ON OPTIMIZING LIFTING MECHANISMS. EVALUATING THE BEHAVIOR OF A LIFTING MECHANISM AT AN ELEVATOR DURING AN EARTHQUAKE [PDF]
Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018 To study the vibrations of the elevator, use various models for the lifting mechanism. Calculate the first pulsation using the Veresceaghin method.Evaluating the behavior of a lifting mechanism at an elevator during an earthquake.The anti-vibration ...
Carmen Elisabeta Radu +2 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Modeling and Numerical Computation of the Longitudinal Non-Linear Dynamics of High-Speed Elevators
Applied SciencesHigh-speed elevator systems comprise numerous components, and vibration issues are prevalent. The evident non-linear behavior resulting from changes in the wire rope length adds complexity to the investigation of elevator dynamics issues.
Zhongxu Tian, Hang He, You Zhou
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source