Results 31 to 40 of about 452 (248)

Techniques for requirements elicitation

[1993] Proceedings of the IEEE International Symposium on Requirements Engineering, 2002
The authors survey and evaluate techniques for eliciting requirements of computer-based systems, paying particular attention to dealing with social issues. The methods surveyed include introspection, interviews, questionnaires, and protocol, conversation, interaction, and discourse analyses.
Goguen, J, Linde, C
openaire   +3 more sources

Estimating Portfolio Risk for Tail Risk Protection Strategies [PDF]

, 2020
We forecast portfolio risk for managing dynamic tail risk protection strategies, based on extreme value theory, expectile regression, Copula-GARCH and dynamic GAS models.
Lohre, Harald, Happersberger, David, Nolte, Ingmar   +2 more
core   +3 more sources

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Risk Measure Examination for Large Losses

Mathematics
The risk measures such as value at risk, and conditional values at risk do not always account for the sensitivity of large losses with certainty, as large losses often break the homogeneity especially seen in an illiquidity risk.
Miwaka Yamashita
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Elicitation Game: Evaluating Capability Elicitation Techniques

CoRR
Capability evaluations are required to understand and regulate AI systems that may be deployed or further developed. Therefore, it is important that evaluations provide an accurate estimation of an AI system's capabilities. However, in numerous cases, previously latent capabilities have been elicited from models, sometimes long after initial release ...
Felix Hofstätter, Teun van der Weij, Jayden Teoh, Rada Djoneva, Henning Bartsch, Francis Rhys Ward   +5 more
openaire   +4 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The risk elicitation puzzle [PDF]

Nature Human Behaviour, 2017
Evidence shows that people's preference for risk changes considerably when measured using different methods, which led us to question whether the common practice of using a single behavioural elicitation method (EM) reflects a valid measure. The present study addresses this question by examining the across-methods consistency of observed risk ...
Pedroni, Andreas, Frey, Renato, Bruhin, Adrian, Dutilh, Gilles, Hertwig, Ralph, Rieskamp, Jörg   +5 more
openaire   +5 more sources