Results 51 to 60 of about 452 (248)
European Journal of Operational ResearchElicitable functionals and (strictly) consistent scoring functions are of interest due to their utility of determining (uniquely) optimal forecasts, and thus the ability to effectively backtest predictions. However, in practice, assuming that a distribution is correctly specified is too strong a belief to reliably hold.
Kathleen E. Miao, Silvana M. Pesenti
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Significance, 2005 Abstract There are various situations in which it may be important to obtain expert opinion about some unknown quantity or quantities. But it is not enough simply to ask the expert for an estimate of the unknown quantity: we also need to know how far from that estimate the true value might be.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Eliciting Mucosal Immunity [PDF]
New England Journal of Medicine, 2011 Eliciting mucosal immunity through vaccination has been problematic. Two recent studies suggest a strategy to achieve this goal.
Wayne I, Lencer, Ulrich H, von Andrian
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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, 2009 Subjective beliefs play a role in many economic decisions. There is a large theoretical literature on the elicitation of beliefs, and an equally large empirical literature. However, there is a gulf between the two. The theoretical literature proposes a range of procedures that can be used to recover beliefs, but stresses the need to make strong ...
Andersen, Steffen +3 more
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Customized Structural Elicitation
, 2021 Established methods for structural elicitation typically rely on code modelling standard graphical models classes, most often Bayesian networks. However, more appropriate models may arise from asking the expert questions in common language about what might relate to what and exploring the logical implications of the statements.
Wilkerson, Rachel L., Smith, Jim Q.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Biases in bias elicitation [PDF]
Communications in Statistics - Theory and Methods, 2018 AbstractWe consider the biases that can arise in bias elicitation when expert assessors make random errors.
Manzi G, Forster M
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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